气候变化领域集成服务门户(CCPortal): Metagenomics to Identify Viral Communities Associated with Porcine Respiratory Disease Complex in Tibetan Pigs in the Tibetan Plateau, China

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DOI	10.3390/pathogens13050404
	Metagenomics to Identify Viral Communities Associated with Porcine Respiratory Disease Complex in Tibetan Pigs in the Tibetan Plateau, China
	Zhou, Long; Zhou, Han; Fan, Yandi; Wang, Jinghao; Zhang, Rui; Guo, Zijing; Li, Yanmin; Kang, Runmin; Zhang, Zhidong; Yang, Danjiao; Liu, Jie
发表日期	2024
EISSN	2076-0817
起始页码	13
结束页码	5
卷号	13 期号:5
英文摘要	Tibetan pig is a unique pig breed native to the Qinghai-Tibet Plateau. To investigate viral communities associated with porcine respiratory disease complex (PRDC), 167 respiratory samples were collected from Tibetan pigs in the Ganzi Tibetan autonomous prefecture of Sichuan province. Following library construction and Illunima Novaseq sequencing, 18 distinct viruses belonging to 15 viral taxonomic families were identified in Tibetan pigs with PRDC. Among the 18 detected viruses, 3 viruses were associated with PRDC, including porcine circovirus type 2 (PCV-2), Torque teno sus virus (TTSuV), and porcine cytomegalovirus (PCMV). The genomic sequences of two PCV-2 strains, three TTSuV strains, and one novel Porprismacovirus strain were assembled by SOAPdenovo software (v2). Sequence alignment and phylogenetic analysis showed that both PCV-2 strains belonged to PCV-2d, three TTSuVs were classified to TTSuV2a and TTSuV2b genotypes, and the Porprismacovirus strain PPMV-SCgz-2022 showed a close genetic relationship with a virus of human origin. Recombination analysis indicated that PPMV-SCgz-2022 may have originated from recombination events between Human 16,806 x 66-213 strain and Porcine 17,668 x 82-593 strain. Furthermore, the high proportion of single infection or co-infection of PCV2/TTSuV2 provides insight into PRDC infection in Tibetan pigs. This is the first report of the viral communities in PRDC-affected Tibetan pigs in this region, and the results provides reference for the prevention and control of respiratory diseases in these animals.
英文关键词	porcine respiratory disease complex; metagenomics; viral community; Tibetan pig
语种	英语
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:001231422300001
来源期刊	PATHOGENS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/298205
作者单位	Southwest Minzu University; Sichuan Academy of Agricultural Sciences (SAAS)
推荐引用方式 GB/T 7714	Zhou, Long,Zhou, Han,Fan, Yandi,et al. Metagenomics to Identify Viral Communities Associated with Porcine Respiratory Disease Complex in Tibetan Pigs in the Tibetan Plateau, China[J],2024,13(5).
APA	Zhou, Long.,Zhou, Han.,Fan, Yandi.,Wang, Jinghao.,Zhang, Rui.,...&Liu, Jie.(2024).Metagenomics to Identify Viral Communities Associated with Porcine Respiratory Disease Complex in Tibetan Pigs in the Tibetan Plateau, China.PATHOGENS,13(5).
MLA	Zhou, Long,et al."Metagenomics to Identify Viral Communities Associated with Porcine Respiratory Disease Complex in Tibetan Pigs in the Tibetan Plateau, China".PATHOGENS 13.5(2024).