气候变化领域集成服务门户(CCPortal): Heat tolerance in Drosophila melanogaster is influenced by oxygen conditions and mutations in cell size control pathways

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DOI	10.1098/rstb.2022.0490
	Heat tolerance in Drosophila melanogaster is influenced by oxygen conditions and mutations in cell size control pathways
	Privalova, Valeriya; Sobczyk, Lukasz; Szlachcic, Ewa; Labecka, Anna Maria; Czarnoleski, Marcin
发表日期	2024
ISSN	0962-8436
EISSN	1471-2970
起始页码	379
结束页码	1896
卷号	379 期号:1896
英文摘要	Understanding metabolic performance limitations is key to explaining the past, present and future of life. We investigated whether heat tolerance in actively flying Drosophila melanogaster is modified by individual differences in cell size and the amount of oxygen in the environment. We used two mutants with loss-of-function mutations in cell size control associated with the target of rapamycin (TOR)/insulin pathways, showing reduced (mutant rictor(Delta 2)) or increased (mutant Mnt(1)) cell size in different body tissues compared to controls. Flies were exposed to a steady increase in temperature under normoxia and hypoxia until they collapsed. The upper critical temperature decreased in response to each mutation type as well as under hypoxia. Females, which have larger cells than males, had lower heat tolerance than males. Altogether, mutations in cell cycle control pathways, differences in cell size and differences in oxygen availability affected heat tolerance, but existing theories on the roles of cell size and tissue oxygenation in metabolic performance can only partially explain our results. A better understanding of how the cellular composition of the body affects metabolism may depend on the development of research models that help separate various interfering physiological parameters from the exclusive influence of cell size.This article is part of the theme issue 'The evolutionary significance of variation in metabolic rates'.
英文关键词	rictor(Delta 2); Mnt(1); TOR; metabolic performance; hypoxia; thermal limits
语种	英语
WOS研究方向	Life Sciences & Biomedicine - Other Topics
WOS类目	Biology
WOS记录号	WOS:001137463800012
来源期刊	PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/297036
作者单位	Jagiellonian University
推荐引用方式 GB/T 7714	Privalova, Valeriya,Sobczyk, Lukasz,Szlachcic, Ewa,et al. Heat tolerance in Drosophila melanogaster is influenced by oxygen conditions and mutations in cell size control pathways[J],2024,379(1896).
APA	Privalova, Valeriya,Sobczyk, Lukasz,Szlachcic, Ewa,Labecka, Anna Maria,&Czarnoleski, Marcin.(2024).Heat tolerance in Drosophila melanogaster is influenced by oxygen conditions and mutations in cell size control pathways.PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES,379(1896).
MLA	Privalova, Valeriya,et al."Heat tolerance in Drosophila melanogaster is influenced by oxygen conditions and mutations in cell size control pathways".PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 379.1896(2024).