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| DOI | 10.1186/s13059-024-03261-3 |
| Genome-wide distribution of 5-hydroxymethyluracil and chromatin accessibility in the Breviolum minutum genome | |
| 发表日期 | 2024 |
| ISSN | 1474-760X |
| 起始页码 | 25 |
| 结束页码 | 1 |
| 卷号 | 25期号:1 |
| 英文摘要 | Background In dinoflagellates, a unique and extremely divergent genomic and nuclear organization has evolved. The highly unusual features of dinoflagellate nuclei and genomes include permanently condensed liquid crystalline chromosomes, primarily packaged by proteins other than histones, genes organized in very long unidirectional gene arrays, a general absence of transcriptional regulation, high abundance of the otherwise very rare DNA modification 5-hydroxymethyluracil (5-hmU), and many others. While most of these fascinating properties are originally identified in the 1970s and 1980s, they have not yet been investigated using modern genomic tools. Results In this work, we address some of the outstanding questions regarding dinoflagellate genome organization by mapping the genome-wide distribution of 5-hmU (using both immunoprecipitation-based and basepair-resolution chemical mapping approaches) and of chromatin accessibility in the genome of the Symbiodiniaceae dinoflagellate Breviolum minutum. We find that the 5-hmU modification is preferentially enriched over certain classes of repetitive elements, often coincides with the boundaries between gene arrays, and is generally correlated with decreased chromatin accessibility, the latter otherwise being largely uniform along the genome. We discuss the potential roles of 5-hmU in the functional organization of dinoflagellate genomes and its relationship to the transcriptional landscape of gene arrays. Conclusions Our results provide the first window into the 5-hmU and chromatin accessibility landscapes in dinoflagellates. |
| 语种 | 英语 |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS记录号 | WOS:001216232800001 |
| 来源期刊 | GENOME BIOLOGY
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/296618 |
| 作者单位 | Stanford University; Stanford University; Stanford University; Carnegie Institution for Science; Stanford University; Stanford University |
| 推荐引用方式 GB/T 7714 | . Genome-wide distribution of 5-hydroxymethyluracil and chromatin accessibility in the Breviolum minutum genome[J],2024,25(1). |
| APA | (2024).Genome-wide distribution of 5-hydroxymethyluracil and chromatin accessibility in the Breviolum minutum genome.GENOME BIOLOGY,25(1). |
| MLA | "Genome-wide distribution of 5-hydroxymethyluracil and chromatin accessibility in the Breviolum minutum genome".GENOME BIOLOGY 25.1(2024). |
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