气候变化领域集成服务门户(CCPortal): Fitness difference between two synonymous mutations of Phytophthora infestansATP6 gene

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DOI	10.1186/s12862-024-02223-4
	Fitness difference between two synonymous mutations of Phytophthora infestansATP6 gene
	Nkurikiyimfura, Oswald; Waheed, Abdul; Fang, Hanmei; Yuan, Xiaoxian; Chen, Lixia; Wang, Yan-Ping; Lu, Guodong; Zhan, Jiasui; Yang, Lina
发表日期	2024
EISSN	2730-7182
起始页码	24
结束页码	1
卷号	24 期号:1
英文摘要	Background Sequence variation produced by mutation provides the ultimate source of natural selection for species adaptation. Unlike nonsynonymous mutation, synonymous mutations are generally considered to be selectively neutral but accumulating evidence suggests they also contribute to species adaptation by regulating the flow of genetic information and the development of functional traits. In this study, we analysed sequence characteristics of ATP6, a housekeeping gene from 139 Phytophthora infestans isolates, and compared the fitness components including metabolic rate, temperature sensitivity, aggressiveness, and fungicide tolerance among synonymous mutations. Results We found that the housekeeping gene exhibited low genetic variation and was represented by two major synonymous mutants at similar frequency (0.496 and 0.468, respectively). The two synonymous mutants were generated by a single nucleotide substitution but differed significantly in fitness as well as temperature-mediated spatial distribution and expression. The synonymous mutant ending in AT was more common in cold regions and was more expressed at lower experimental temperature than the synonymous mutant ending in GC and vice versa. Conclusion Our results are consistent with the argument that synonymous mutations can modulate the adaptive evolution of species including pathogens and have important implications for sustainable disease management, especially under climate change.
英文关键词	Disease management; Oomycete; Population genetics; Fitness of species; Neutral theory; Thermal-mediated adaptation; Plant pathogen
语种	英语
WOS研究方向	Environmental Sciences & Ecology ; Evolutionary Biology ; Genetics & Heredity
WOS类目	Ecology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号	WOS:001186181200001
来源期刊	BMC ECOLOGY AND EVOLUTION
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/295621
作者单位	Fujian Agriculture & Forestry University; Minjiang University; Fujian Agriculture & Forestry University; Chengdu Normal University; Fujian Agriculture & Forestry University; Swedish University of Agricultural Sciences
推荐引用方式 GB/T 7714	Nkurikiyimfura, Oswald,Waheed, Abdul,Fang, Hanmei,et al. Fitness difference between two synonymous mutations of Phytophthora infestansATP6 gene[J],2024,24(1).
APA	Nkurikiyimfura, Oswald.,Waheed, Abdul.,Fang, Hanmei.,Yuan, Xiaoxian.,Chen, Lixia.,...&Yang, Lina.(2024).Fitness difference between two synonymous mutations of Phytophthora infestansATP6 gene.BMC ECOLOGY AND EVOLUTION,24(1).
MLA	Nkurikiyimfura, Oswald,et al."Fitness difference between two synonymous mutations of Phytophthora infestansATP6 gene".BMC ECOLOGY AND EVOLUTION 24.1(2024).