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| DOI | 10.1186/s12862-024-02223-4 |
| Fitness difference between two synonymous mutations of Phytophthora infestansATP6 gene | |
| 发表日期 | 2024 |
| EISSN | 2730-7182 |
| 起始页码 | 24 |
| 结束页码 | 1 |
| 卷号 | 24期号:1 |
| 英文摘要 | Background Sequence variation produced by mutation provides the ultimate source of natural selection for species adaptation. Unlike nonsynonymous mutation, synonymous mutations are generally considered to be selectively neutral but accumulating evidence suggests they also contribute to species adaptation by regulating the flow of genetic information and the development of functional traits. In this study, we analysed sequence characteristics of ATP6, a housekeeping gene from 139 Phytophthora infestans isolates, and compared the fitness components including metabolic rate, temperature sensitivity, aggressiveness, and fungicide tolerance among synonymous mutations. Results We found that the housekeeping gene exhibited low genetic variation and was represented by two major synonymous mutants at similar frequency (0.496 and 0.468, respectively). The two synonymous mutants were generated by a single nucleotide substitution but differed significantly in fitness as well as temperature-mediated spatial distribution and expression. The synonymous mutant ending in AT was more common in cold regions and was more expressed at lower experimental temperature than the synonymous mutant ending in GC and vice versa. Conclusion Our results are consistent with the argument that synonymous mutations can modulate the adaptive evolution of species including pathogens and have important implications for sustainable disease management, especially under climate change. |
| 英文关键词 | Disease management; Oomycete; Population genetics; Fitness of species; Neutral theory; Thermal-mediated adaptation; Plant pathogen |
| 语种 | 英语 |
| WOS研究方向 | Environmental Sciences & Ecology ; Evolutionary Biology ; Genetics & Heredity |
| WOS类目 | Ecology ; Evolutionary Biology ; Genetics & Heredity |
| WOS记录号 | WOS:001186181200001 |
| 来源期刊 | BMC ECOLOGY AND EVOLUTION
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/295620 |
| 作者单位 | Fujian Agriculture & Forestry University; Minjiang University; Fujian Agriculture & Forestry University; Chengdu Normal University; Fujian Agriculture & Forestry University; Swedish University of Agricultural Sciences |
| 推荐引用方式 GB/T 7714 | . Fitness difference between two synonymous mutations of Phytophthora infestansATP6 gene[J],2024,24(1). |
| APA | (2024).Fitness difference between two synonymous mutations of Phytophthora infestansATP6 gene.BMC ECOLOGY AND EVOLUTION,24(1). |
| MLA | "Fitness difference between two synonymous mutations of Phytophthora infestansATP6 gene".BMC ECOLOGY AND EVOLUTION 24.1(2024). |
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