气候变化领域集成服务门户(CCPortal): A Drug Discovery Approach to a Reveal Novel Antioxidant Natural Source: The Case of Chestnut Burr Biomass

CCPortal

DOI	10.3390/ijms25052517
	A Drug Discovery Approach to a Reveal Novel Antioxidant Natural Source: The Case of Chestnut Burr Biomass
	Trezza, Alfonso; Geminiani, Michela; Cutrera, Giuseppe; Dreassi, Elena; Frusciante, Luisa; Lamponi, Stefania; Spiga, Ottavia; Santucci, Annalisa
发表日期	2024
ISSN	1661-6596
EISSN	1422-0067
起始页码	25
结束页码	5
卷号	25 期号:5
英文摘要	Currently, many environmental and energy-related problems are threatening the future of our planet. In October 2022, the Worldmeter recorded the world population as 7.9 billion people, estimating that there will be an increase of 2 billion by 2057. The rapid growth of the population and the continuous increase in needs are causing worrying conditions, such as pollution, climate change, global warming, waste disposal, and natural resource reduction. Looking for novel and innovative methods to overcome these global troubles is a must for our common welfare. The circular bioeconomy represents a promising strategy to alleviate the current conditions using biomass-like natural wastes to replace commercial products that have a negative effect on our ecological footprint. Applying the circular bioeconomy concept, we propose an integrated in silico and in vitro approach to identify antioxidant bioactive compounds extracted from chestnut burrs (an agroforest waste) and their potential biological targets. Our study provides a novel and robust strategy developed within the circular bioeconomy concept aimed at target and drug discovery for a wide range of diseases. Our study could open new frontiers in the circular bioeconomy related to target and drug discovery, offering new ideas for sustainable scientific research aimed at identifying novel therapeutical strategies.
英文关键词	drug and target discovery; molecular modeling; docking and molecular dynamics simulation; chestnut burr; natural bioproduct; bioeconomy; polyphenols; antioxidant
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:001182711900001
来源期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/295300
作者单位	University of Siena; University of Siena
推荐引用方式 GB/T 7714	Trezza, Alfonso,Geminiani, Michela,Cutrera, Giuseppe,et al. A Drug Discovery Approach to a Reveal Novel Antioxidant Natural Source: The Case of Chestnut Burr Biomass[J],2024,25(5).
APA	Trezza, Alfonso.,Geminiani, Michela.,Cutrera, Giuseppe.,Dreassi, Elena.,Frusciante, Luisa.,...&Santucci, Annalisa.(2024).A Drug Discovery Approach to a Reveal Novel Antioxidant Natural Source: The Case of Chestnut Burr Biomass.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,25(5).
MLA	Trezza, Alfonso,et al."A Drug Discovery Approach to a Reveal Novel Antioxidant Natural Source: The Case of Chestnut Burr Biomass".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 25.5(2024).