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| DOI | 10.1038/s41598-024-57828-y |
| Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations | |
| 发表日期 | 2024 |
| ISSN | 2045-2322 |
| 起始页码 | 14 |
| 结束页码 | 1 |
| 卷号 | 14期号:1 |
| 英文摘要 | Recent experimental data shows that hesperetin, a citrus flavonoid, affects potassium channels and can prolong the QTc interval in humans. Therefore, in the present study we investigated the effects of hesperetin on various transmembrane ionic currents and on ventricular action potentials. Transmembrane current measurements and action potential recordings were performed by patch-clamp and the conventional microelectrode techniques in dog and rabbit ventricular preparations. At 10 mu M concentration hesperetin did not, however, at 30 mu M significantly decreased the amplitude of the IK1, Ito, IKr potassium currents. Hesperetin at 3-30 mu M significantly and in a concentration-dependent manner reduced the amplitude of the IKs current. The drug significantly decreased the amplitudes of the INaL and ICaL currents at 30 mu M. Hesperetin (10 and 30 mu M) did not change the action potential duration in normal preparations, however, in preparations where the repolarization reserve had been previously attenuated by 100 nM dofetilide and 1 mu g/ml veratrine, caused a moderate but significant prolongation of repolarization. These results suggest that hesperetin at close to relevant concentrations inhibits the IKs outward potassium current and thereby reduces repolarization reserve. This effect in certain specific situations may prolong the QT interval and consequently may enhance proarrhythmic risk. |
| 英文关键词 | Hesperetin; Citrus flavonoids; Repolarization reserve; Proarrhythmia; Transmembrane ionic currents |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:001196356400015 |
| 来源期刊 | SCIENTIFIC REPORTS
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/295039 |
| 作者单位 | Szeged University |
| 推荐引用方式 GB/T 7714 | . Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations[J],2024,14(1). |
| APA | (2024).Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations.SCIENTIFIC REPORTS,14(1). |
| MLA | "Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations".SCIENTIFIC REPORTS 14.1(2024). |
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