气候变化领域集成服务门户(CCPortal): Effects of cold acclimation on serum biochemical parameters and metabolite profiles in Schizothorax prenanti

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DOI	10.1186/s12864-024-10483-z
	Effects of cold acclimation on serum biochemical parameters and metabolite profiles in Schizothorax prenanti
	Wang, Aiyu; Zhang, Run; Zhang, Xianshu; Chen, Chunjie; Gong, Quan; Wang, Linjie; Wang, Yan
发表日期	2024
ISSN	1471-2164
起始页码	25
结束页码	1
卷号	25 期号:1
英文摘要	Background Environmental temperature is critical in regulating biological functions in fish. S. prenanti is a kind of cold-water fish, but of which we have little knowledge about the metabolic adaptation and physiological responses to long-term cold acclimation. Results In this study, we determined the physiological responses of S. prenanti serum after 30 days of exposure to 6degree celsius. Compared with the control group, the levels of TC, TG, and LDL-C in the serum were significantly (P < 0.05) increased, and the level of glucose was significantly (P < 0.05) decreased under cold acclimation. Cold acclimation had no effect on the gene expression of pro-inflammatory factors and anti-inflammatory factors of S. prenanti. Metabolomics analysis by LC-MS showed that a total of 60 differential expressed metabolites were identified after cold acclimation, which involved in biosynthesis of amino acids, biosynthesis of unsaturated fatty acids, steroid degradation, purine metabolism, and citrate cycle pathways. Conclusion The results indicate that cold acclimation can alter serum metabolites and metabolic pathways to alter energy metabolism and provide insights for the physiological regulation of cold-water fish in response to cold acclimation.
英文关键词	Cold acclimation; Metabolomics; Amino acids; Unsaturated fatty acids; Schizothorax prenanti
语种	英语
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:001236839800002
来源期刊	BMC GENOMICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/294504
作者单位	Sichuan Agricultural University; Sichuan Academy of Agricultural Sciences (SAAS)
推荐引用方式 GB/T 7714	Wang, Aiyu,Zhang, Run,Zhang, Xianshu,et al. Effects of cold acclimation on serum biochemical parameters and metabolite profiles in Schizothorax prenanti[J],2024,25(1).
APA	Wang, Aiyu.,Zhang, Run.,Zhang, Xianshu.,Chen, Chunjie.,Gong, Quan.,...&Wang, Yan.(2024).Effects of cold acclimation on serum biochemical parameters and metabolite profiles in Schizothorax prenanti.BMC GENOMICS,25(1).
MLA	Wang, Aiyu,et al."Effects of cold acclimation on serum biochemical parameters and metabolite profiles in Schizothorax prenanti".BMC GENOMICS 25.1(2024).