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| DOI | 10.1093/bbb/zbae055 |
| Malus toringoides (Rehd.) Hughes decoction alleviates isoproterenol-induced cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis via the HK1/NLRP3 signaling pathway | |
| 发表日期 | 2024 |
| ISSN | 0916-8451 |
| EISSN | 1347-6947 |
| 英文摘要 | Malus toringoides (Rehd.) Hughes, called Eseye (Ese), is a traditional medicinal plant from the Tibet province of China that has proven effective in treating cardiac conditions due to its anti-inflammatory, antioxidative, and antiapoptotic properties. In this study, we explored the underlying protective mechanisms of Ese decoction in isoproterenol (ISO)-induced cardiac fibrosis (CF) and established the fact that treatment with an Ese decoction attenuated tissue injury, decreased the release of IL-1 beta, IL-18, TNF-alpha, and caspase-3, and elevated the Bax/Bcl-2 ratio in CF mice. We also found that with Ese treatment damage to the mitochondrial ultrastructure of myocardium was alleviated, and the level of reactive oxygen species was markedly diminished. Ese inhibited the expression of proteins associated with pyroptosis by the HK1/NLRP3 signaling pathway and also improved CF. Due to the anti-inflammatory, antioxidative, and antiapoptotic characteristics of Ese decoction, we found that Ese protected against ISO-induced CF, by inhibiting inflammation and pyroptosis as mediated by the HK1/NLRP3 signaling pathway. Graphical Abstract Malus toringoides (Rehd.) Hughes decoction alleviates cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis. |
| 英文关键词 | cardiac fibrosis; Eseye; anti-inflammation; pyroptosis |
| 语种 | 英语 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry ; Food Science & Technology |
| WOS类目 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry, Applied ; Food Science & Technology |
| WOS记录号 | WOS:001232952900001 |
| 来源期刊 | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/293876 |
| 作者单位 | Hebei Chemical & Pharmaceutical College; Hebei University of Chinese Medicine |
| 推荐引用方式 GB/T 7714 | . Malus toringoides (Rehd.) Hughes decoction alleviates isoproterenol-induced cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis via the HK1/NLRP3 signaling pathway[J],2024. |
| APA | (2024).Malus toringoides (Rehd.) Hughes decoction alleviates isoproterenol-induced cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis via the HK1/NLRP3 signaling pathway.BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY. |
| MLA | "Malus toringoides (Rehd.) Hughes decoction alleviates isoproterenol-induced cardiac fibrosis by inhibiting cardiomyocyte inflammation and pyroptosis via the HK1/NLRP3 signaling pathway".BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2024). |
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