气候变化领域集成服务门户(CCPortal): Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells

CCPortal

DOI	10.1038/s41564-024-01672-3
	Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
	Monteil, Vanessa M.; Wright, Shane C.; Dyczynski, Matheus; Kellner, Max J.; Appelberg, Sofia; Platzer, Sebastian W.; Ibrahim, Ahmed; Kwon, Hyesoo; Pittarokoilis, Ioannis; Mirandola, Mattia; Michlits, Georg; Devignot, Stephanie; Elder, Elizabeth; Abdurahman, Samir; Bereczky, Sandor; Bagci, Binnur; Youhanna, Sonia; Aastrup, Teodor; Lauschke, Volker M.; Salata, Cristiano; Elaldi, Nazif; Weber, Friedemann; Monserrat, Nuria; Hawman, David W.; Feldmann, Heinz; Horn, Moritz; Penninger, Josef M.; Mirazimi, Ali
发表日期	2024
ISSN	2058-5276
起始页码	9
结束页码	5
卷号	9 期号:5
英文摘要	Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean-Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing a vital role in CCHFV infection in cell culture and blood vessel organoids. The interaction between CCHFV and LDLR is highly specific, with other members of the LDLR protein family failing to bind to or neutralize the virus. Biosensor experiments demonstrate that LDLR specifically binds the surface glycoproteins of CCHFV. Importantly, mice lacking LDLR exhibit a delay in CCHFV-induced disease. Furthermore, we identified the presence of Apolipoprotein E (ApoE) on CCHFV particles. Our findings highlight the essential role of LDLR in CCHFV infection, irrespective of ApoE presence, when the virus is produced in tick cells. This discovery holds profound implications for the development of future therapies against CCHFV. Laboratory and clinical strains of Crimean-Congo haemorrhagic fever virus use LDLR to bind and enter host cells in blood vessel organoids and mice. Infection can also occur through ApoE, possibly present on virus particles.
语种	英语
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:001194694400002
来源期刊	NATURE MICROBIOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/293547
作者单位	Karolinska Institutet; Karolinska Institutet; Karolinska University Hospital; Public Health Agency of Sweden; Karolinska Institutet; Austrian Academy of Sciences; Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); Vienna Biocenter (VBC); University of Vienna; Medical University of Vienna; National Veterinary Institute SVA; University of Padua; Cumhuriyet University; Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Cumhuriyet University; Justus Liebig University Giessen; University of Barcelona; Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya; University of Barcelona; ICREA; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Medical University of Vienna; Helmholtz Association; Helmholtz-Center for Infection Research; University of British Columbia
推荐引用方式 GB/T 7714	Monteil, Vanessa M.,Wright, Shane C.,Dyczynski, Matheus,et al. Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells[J],2024,9(5).
APA	Monteil, Vanessa M..,Wright, Shane C..,Dyczynski, Matheus.,Kellner, Max J..,Appelberg, Sofia.,...&Mirazimi, Ali.(2024).Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells.NATURE MICROBIOLOGY,9(5).
MLA	Monteil, Vanessa M.,et al."Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells".NATURE MICROBIOLOGY 9.5(2024).