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DOI	10.3389/fgene.2024.1302554
	Uncovering rearrangements in the Tibetan antelope via population-derived genome refinement and comparative analysis with homologous species
	Chen, Jiarui; Wang, Shuwen; Wang, Dong; Chiu, Yunkang; Yang, Nan; Lian, Xinming; Zhao, Zicheng; Wei, Qing
发表日期	2024
EISSN	1664-8021
起始页码	15
卷号	15
英文摘要	Introduction: The Tibetan antelope (Pantholops hodgsonii) is a remarkable mammal thriving in the extreme Qinghai-Tibet Plateau conditions. Despite the availability of its genome sequence, limitations in the scaffold-level assembly have hindered a comprehensive understanding of its genomics. Moreover, comparative analyses with other Bovidae species are lacking, along with insights into genome rearrangements in the Tibetan antelope.Methods: Addressing these gaps, we present a multifaceted approach by refining the Tibetan Antelope genome through linkage disequilibrium analysis with data from 15 newly sequenced samples.Results: The scaffold N50 of the refined reference is 3.2 Mbp, surpassing the previous version by 1.15-fold. Our annotation analysis resulted in 50,750 genes, encompassing 29,324 novel genes not previously study. Comparative analyses reveal 182 unique rearrangements within the scaffolds, contributing to our understanding of evolutionary dynamics and species-specific adaptations. Furthermore, by conducting detailed genomic comparisons and reconstructing rearrangements, we have successfully pioneered the reconstruction of the X-chromosome in the Tibetan antelope.Discussion: This effort enhances our comprehension of the genomic landscape of this species.
英文关键词	Tibetan antelope; genome refinement; genome comparison; genome rearrangements; linkage disequilibrium
语种	英语
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:001173846900001
来源期刊	FRONTIERS IN GENETICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/293085
作者单位	Qinghai University; Qinghai University; Chinese Academy of Sciences; Qinghai Normal University; Chinese Academy of Sciences; Beijing Institute of Genomics, CAS; Chinese Academy of Sciences; Beijing Institute of Genomics, CAS
推荐引用方式 GB/T 7714	Chen, Jiarui,Wang, Shuwen,Wang, Dong,et al. Uncovering rearrangements in the Tibetan antelope via population-derived genome refinement and comparative analysis with homologous species[J],2024,15.
APA	Chen, Jiarui.,Wang, Shuwen.,Wang, Dong.,Chiu, Yunkang.,Yang, Nan.,...&Wei, Qing.(2024).Uncovering rearrangements in the Tibetan antelope via population-derived genome refinement and comparative analysis with homologous species.FRONTIERS IN GENETICS,15.
MLA	Chen, Jiarui,et al."Uncovering rearrangements in the Tibetan antelope via population-derived genome refinement and comparative analysis with homologous species".FRONTIERS IN GENETICS 15(2024).