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| DOI | 10.3389/fgene.2024.1302554 |
| Uncovering rearrangements in the Tibetan antelope via population-derived genome refinement and comparative analysis with homologous species | |
| 发表日期 | 2024 |
| EISSN | 1664-8021 |
| 起始页码 | 15 |
| 卷号 | 15 |
| 英文摘要 | Introduction: The Tibetan antelope (Pantholops hodgsonii) is a remarkable mammal thriving in the extreme Qinghai-Tibet Plateau conditions. Despite the availability of its genome sequence, limitations in the scaffold-level assembly have hindered a comprehensive understanding of its genomics. Moreover, comparative analyses with other Bovidae species are lacking, along with insights into genome rearrangements in the Tibetan antelope.Methods: Addressing these gaps, we present a multifaceted approach by refining the Tibetan Antelope genome through linkage disequilibrium analysis with data from 15 newly sequenced samples.Results: The scaffold N50 of the refined reference is 3.2 Mbp, surpassing the previous version by 1.15-fold. Our annotation analysis resulted in 50,750 genes, encompassing 29,324 novel genes not previously study. Comparative analyses reveal 182 unique rearrangements within the scaffolds, contributing to our understanding of evolutionary dynamics and species-specific adaptations. Furthermore, by conducting detailed genomic comparisons and reconstructing rearrangements, we have successfully pioneered the reconstruction of the X-chromosome in the Tibetan antelope.Discussion: This effort enhances our comprehension of the genomic landscape of this species. |
| 英文关键词 | Tibetan antelope; genome refinement; genome comparison; genome rearrangements; linkage disequilibrium |
| 语种 | 英语 |
| WOS研究方向 | Genetics & Heredity |
| WOS类目 | Genetics & Heredity |
| WOS记录号 | WOS:001173846900001 |
| 来源期刊 | FRONTIERS IN GENETICS
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/293084 |
| 作者单位 | Qinghai University; Qinghai University; Chinese Academy of Sciences; Qinghai Normal University; Chinese Academy of Sciences; Beijing Institute of Genomics, CAS; Chinese Academy of Sciences; Beijing Institute of Genomics, CAS |
| 推荐引用方式 GB/T 7714 | . Uncovering rearrangements in the Tibetan antelope via population-derived genome refinement and comparative analysis with homologous species[J],2024,15. |
| APA | (2024).Uncovering rearrangements in the Tibetan antelope via population-derived genome refinement and comparative analysis with homologous species.FRONTIERS IN GENETICS,15. |
| MLA | "Uncovering rearrangements in the Tibetan antelope via population-derived genome refinement and comparative analysis with homologous species".FRONTIERS IN GENETICS 15(2024). |
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