气候变化领域集成服务门户(CCPortal): High-throughput characterization of bacterial responses to complex mixtures of chemical pollutants

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DOI	10.1038/s41564-024-01626-9
	High-throughput characterization of bacterial responses to complex mixtures of chemical pollutants
	Smith, Thomas P.; Clegg, Tom; Ransome, Emma; Martin-Lilley, Thomas; Rosindell, James; Woodward, Guy; Pawar, Samraat; Bell, Thomas
发表日期	2024
ISSN	2058-5276
起始页码	9
结束页码	4
卷号	9 期号:4
英文摘要	Our understanding of how microbes respond to micropollutants, such as pesticides, is almost wholly based on single-species responses to individual chemicals. However, in natural environments, microbes experience multiple pollutants simultaneously. Here we perform a matrix of multi-stressor experiments by assaying the growth of model and non-model strains of bacteria in all 255 combinations of 8 chemical stressors (antibiotics, herbicides, fungicides and pesticides). We found that bacterial strains responded in different ways to stressor mixtures, which could not be predicted simply from their phylogenetic relatedness. Increasingly complex chemical mixtures were both more likely to negatively impact bacterial growth in monoculture and more likely to reveal net interactive effects. A mixed co-culture of strains proved more resilient to increasingly complex mixtures and revealed fewer interactions in the growth response. These results show predictability in microbial population responses to chemical stressors and could increase the utility of next-generation eco-toxicological assays. Testing 255 combinations of chemicals versus bacterial communities shows species diversity contributes to resilience against increasingly complex stressor mixtures.
语种	英语
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:001187086000001
来源期刊	NATURE MICROBIOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/292975
作者单位	Imperial College London
推荐引用方式 GB/T 7714	Smith, Thomas P.,Clegg, Tom,Ransome, Emma,et al. High-throughput characterization of bacterial responses to complex mixtures of chemical pollutants[J],2024,9(4).
APA	Smith, Thomas P..,Clegg, Tom.,Ransome, Emma.,Martin-Lilley, Thomas.,Rosindell, James.,...&Bell, Thomas.(2024).High-throughput characterization of bacterial responses to complex mixtures of chemical pollutants.NATURE MICROBIOLOGY,9(4).
MLA	Smith, Thomas P.,et al."High-throughput characterization of bacterial responses to complex mixtures of chemical pollutants".NATURE MICROBIOLOGY 9.4(2024).