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DOI | 10.1038/s41467-024-46890-9 |
Metal free cross-dehydrogenative N-N coupling of primary amides with Lewis basic amines | |
发表日期 | 2024 |
EISSN | 2041-1723 |
起始页码 | 15 |
结束页码 | 1 |
卷号 | 15期号:1 |
英文摘要 | Hydrazides, N-N containing structural motifs, are important due to their presence in a wide variety of biologically significant compounds. While the homo N-N coupling of two NH moieties to form the hydrazide N-N bond is well developed, the cross-dehydrogenative hetero N-N coupling remains very unevolved. Here we present an efficient intermolecular N-N cross-coupling of a series of primary benzamides with broad range of Lewis basic primary and secondary amines using PhI(OAc)2 as both a terminal oxidant and a cross-coupling mediator, without the need for metal catalysts, high temperatures, and inert atmospheres, and with substantial potential for use in the late-stage functionalization of drugs. While the homo N-N coupling of two NH moieties to form the hydrazide N-N bond is well developed, the crossdehydrogenative hetero N-N coupling remains unevolved. Here the authors present an efficient, PhI(OAc)2-mediated intermolecular N-N cross-coupling of primary benzamides with primary and secondary amines. |
语种 | 英语 |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:001191874200005 |
来源期刊 | NATURE COMMUNICATIONS
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文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/292932 |
作者单位 | Linnaeus University |
推荐引用方式 GB/T 7714 | . Metal free cross-dehydrogenative N-N coupling of primary amides with Lewis basic amines[J],2024,15(1). |
APA | (2024).Metal free cross-dehydrogenative N-N coupling of primary amides with Lewis basic amines.NATURE COMMUNICATIONS,15(1). |
MLA | "Metal free cross-dehydrogenative N-N coupling of primary amides with Lewis basic amines".NATURE COMMUNICATIONS 15.1(2024). |
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