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| DOI | 10.1016/j.seppur.2024.126439 |
| Continuous downstream processing | |
| Jungbauer, Alois; Satzer, Peter; Duerauer, Astrid; Azevedo, Ana; Aires-Barros, Raquel; Nilsson, Bernt; Farid, Suzy; Goldrick, Stephen; Ottens, Marcel; Sponchioni, Mattia; Lahore, Hector Marcelo Fernandez | |
| 发表日期 | 2024 |
| ISSN | 1383-5866 |
| EISSN | 1873-3794 |
| 起始页码 | 338 |
| 卷号 | 338 |
| 英文摘要 | The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time frame with high quality within a tight regulatory framework. Bioprocesses are highly complex, the level of automation is moderate, and there is constant pressure to improve efficiency and costs. In addition, climate change and resource scarcity mandate a reduction in the environmental footprint of bioprocesses and production facilities. In the biopharmaceutical industry, two extreme production scenarios are applied: a fully disposable factory with the characteristics of full flexibility and speed, or a fixed large-scale plant with high capacity. Forward-looking solutions and ideas will be discussed how to combine new processes and environmental friendliness for the benefit of the patient, security of supply and profitability. The concept will be extended to large scale production of proteins for food and non-pharma applications, e.g., in material science and a roadmap towards a future plant will be laid out. |
| 英文关键词 | Continuous integrated biomanufacturing; Scale down; Microfluidics; Economics; Environmental footprint |
| 语种 | 英语 |
| WOS研究方向 | Engineering |
| WOS类目 | Engineering, Chemical |
| WOS记录号 | WOS:001178129100001 |
| 来源期刊 | SEPARATION AND PURIFICATION TECHNOLOGY
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| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/292070 |
| 作者单位 | Austrian Centre of Industrial Biotechnology; BOKU University; Universidade de Lisboa; Lund University; University of London; University College London; Delft University of Technology; Polytechnic University of Milan; Austrian Centre of Industrial Biotechnology |
| 推荐引用方式 GB/T 7714 | Jungbauer, Alois,Satzer, Peter,Duerauer, Astrid,et al. Continuous downstream processing[J],2024,338. |
| APA | Jungbauer, Alois.,Satzer, Peter.,Duerauer, Astrid.,Azevedo, Ana.,Aires-Barros, Raquel.,...&Lahore, Hector Marcelo Fernandez.(2024).Continuous downstream processing.SEPARATION AND PURIFICATION TECHNOLOGY,338. |
| MLA | Jungbauer, Alois,et al."Continuous downstream processing".SEPARATION AND PURIFICATION TECHNOLOGY 338(2024). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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