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| DOI | 10.3389/fnut.2024.1315555 |
| Challenges and opportunities in cell expansion for cultivated meat | |
| 发表日期 | 2024 |
| ISSN | 2296-861X |
| 起始页码 | 11 |
| 卷号 | 11 |
| 英文摘要 | The cultivation of meat using in vitro grown animal stem cells offers a promising solution to pressing global concerns around climate change, ethical considerations, and public health. However, cultivated meat introduces an unprecedented necessity: the generation of mass scales of cellular biomaterial, achieved by fostering cell proliferation within bioreactors. Existing methods for in vitro cell proliferation encounter substantial challenges in terms of both scalability and economic viability. Within this perspective, we discuss the current landscape of cell proliferation optimization, focusing on approaches pertinent to cellular agriculture. We examine the mechanisms governing proliferation rates, while also addressing intrinsic and conditional rate limitations. Furthermore, we expound upon prospective strategies that could lead to a significant enhancement of the overall scalability and cost-efficiency of the cell proliferation phase within the cultivated meat production process. By exploring knowledge from basic cell cycle studies, pathological contexts and tissue engineering, we may identify innovative solutions toward optimizing cell expansion. |
| 英文关键词 | in vitro cultivation; proliferation; self-renewal; cell cylce; genetic regulation |
| 语种 | 英语 |
| WOS研究方向 | Nutrition & Dietetics |
| WOS类目 | Nutrition & Dietetics |
| WOS记录号 | WOS:001169127600001 |
| 来源期刊 | FRONTIERS IN NUTRITION
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/291966 |
| 作者单位 | Tel Aviv University; VOLCANI INSTITUTE OF AGRICULTURAL RESEARCH |
| 推荐引用方式 GB/T 7714 | . Challenges and opportunities in cell expansion for cultivated meat[J],2024,11. |
| APA | (2024).Challenges and opportunities in cell expansion for cultivated meat.FRONTIERS IN NUTRITION,11. |
| MLA | "Challenges and opportunities in cell expansion for cultivated meat".FRONTIERS IN NUTRITION 11(2024). |
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