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| DOI | 10.1021/acs.jnatprod.4c00214 |
| Bioactivity-Based Molecular Networking-Guided Isolation of Epicolidines A-C from the Endophytic Fungus Epicoccum sp. 1-042 | |
| 发表日期 | 2024 |
| ISSN | 0163-3864 |
| EISSN | 1520-6025 |
| 英文摘要 | Bioactivity-based molecular networking-guided fractionation enabled the isolation of three new polycyclic tetramic acids bearing cis-decalin, epicolidines A-C (1-3), along with one known compound, PF 1052 (4), from the endophytic fungus Epicoccum sp. 1-042 collected in Tibet, China. Their structures were assigned on the basis of extensive spectroscopic data, partial hydrolysis, advanced Marfey's method, quantum chemistry calculations, and X-ray diffraction analysis. Compounds 2-4 displayed promising activities against Gram-positive bacteria in vitro. Particularly, compound 4 displayed remarkable potential against vancomycin-resistant Enterococcus faecium (VRE) with an MIC value of 0.25 mu g/mL, lower than the MIC (0.5 mu g/mL) of the antibiotic combination quinupristin/dalfopristin (Q/D). In a further in vivo study, compound 4 increased the survival rate to 100% in the VRE-G. mellonella infection model at a concentration of 10 mg/kg. |
| 语种 | 英语 |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| WOS类目 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS记录号 | WOS:001231818000001 |
| 来源期刊 | JOURNAL OF NATURAL PRODUCTS
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| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/291361 |
| 作者单位 | Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College |
| 推荐引用方式 GB/T 7714 | . Bioactivity-Based Molecular Networking-Guided Isolation of Epicolidines A-C from the Endophytic Fungus Epicoccum sp. 1-042[J],2024. |
| APA | (2024).Bioactivity-Based Molecular Networking-Guided Isolation of Epicolidines A-C from the Endophytic Fungus Epicoccum sp. 1-042.JOURNAL OF NATURAL PRODUCTS. |
| MLA | "Bioactivity-Based Molecular Networking-Guided Isolation of Epicolidines A-C from the Endophytic Fungus Epicoccum sp. 1-042".JOURNAL OF NATURAL PRODUCTS (2024). |
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