气候变化领域集成服务门户(CCPortal): Exposure to ambient temperature and heat index in relation to DNA methylation age: A population-based study in Taiwan

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DOI	10.1016/j.envint.2024.108581
	Exposure to ambient temperature and heat index in relation to DNA methylation age: A population-based study in Taiwan
	Chiu, Kuan-Chih; Hsieh, Ming -Shun; Huang, Yen-Tsung; Liu, Chen -Yu
发表日期	2024
ISSN	0160-4120
EISSN	1873-6750
起始页码	186
卷号	186
英文摘要	Background: Climate change caused an increase in ambient temperature in the past decades. Exposure to high ambient temperature could result in biological aging, but relevant studies in a warm environment were lacking. We aimed to study the exposure effects of ambient temperature and heat index (HI) in relation to age acceleration in Taiwan, a subtropical island in Asia. Methods: The study included 2,084 participants from Taiwan Biobank. Daily temperature and relative humidity data were collected from weather monitoring stations. Individual residential exposure was estimated by ordinary kriging. Moving averages of ambient temperature and HI from 1 to 180 days prior to enrollment were calculated to estimate the exposure effects in multiple time periods. Age acceleration was defined as the difference between DNA methylation age and chronological age. DNA methylation age was calculated by the Horvath's, Hannum's, Weidner's, ELOVL2, FHL2, phenotypic (Pheno), Skin & blood, and GrimAge2 (Grim2) DNA methylation age algorithms. Multivariable linear regression models, generalized additive models (GAMs), and distributed lag non-linear models (DLNMs) were conducted to estimate the effects of ambient temperature and HI exposures in relation to age acceleration. Results: Exposure to high ambient temperature and HI were associated with increased age acceleration, and the associations were stronger in prolonged exposure. The heat stress days with maximum HI in caution (80-90 degrees F), extreme caution (90-103 degrees F), danger (103-124 degrees F), and extreme danger (>124 degrees F) were also associated with increased age acceleration, especially in the extreme danger days. Each extreme danger day was associated with 571.38 (95 % CI: 42.63-1100.13), 528.02 (95 % CI: 36.16-1019.87), 43.9 (95 % CI: 0.28-87.52), 16.82 (95 % CI: 2.36-31.28) and 15.52 (95 % CI: 2.17-28.88) days increase in the Horvath's, Hannum's, Weidner's, Pheno, and Skin & blood age acceleration, respectively. Conclusion: High ambient temperature and HI may accelerate biological aging.
英文关键词	Ambient temperature; Heat index; Biological aging; DNA methylation age; Taiwan Biobank
语种	英语
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:001219284900001
来源期刊	ENVIRONMENT INTERNATIONAL
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/290968
作者单位	National Taiwan University; Taipei Veterans General Hospital; Taipei Veterans General Hospital; National Yang Ming Chiao Tung University; Academia Sinica - Taiwan; National Taiwan University; National Taiwan University; National Taiwan University; National Taiwan University
推荐引用方式 GB/T 7714	Chiu, Kuan-Chih,Hsieh, Ming -Shun,Huang, Yen-Tsung,et al. Exposure to ambient temperature and heat index in relation to DNA methylation age: A population-based study in Taiwan[J],2024,186.
APA	Chiu, Kuan-Chih,Hsieh, Ming -Shun,Huang, Yen-Tsung,&Liu, Chen -Yu.(2024).Exposure to ambient temperature and heat index in relation to DNA methylation age: A population-based study in Taiwan.ENVIRONMENT INTERNATIONAL,186.
MLA	Chiu, Kuan-Chih,et al."Exposure to ambient temperature and heat index in relation to DNA methylation age: A population-based study in Taiwan".ENVIRONMENT INTERNATIONAL 186(2024).