气候变化领域集成服务门户(CCPortal): Mixed Patterns of Intergenerational DNA Methylation Inheritance in Acropora

CCPortal

DOI	10.1093/molbev/msae008
	Mixed Patterns of Intergenerational DNA Methylation Inheritance in Acropora
	Peterson, Christopher R.; Scott, Carly B.; Ghaffari, Rashin; Dixon, Groves; Matz, Mikhail, V
发表日期	2024
ISSN	0737-4038
EISSN	1537-1719
起始页码	41
结束页码	2
卷号	41 期号:2
英文摘要	For sessile organisms at high risk from climate change, phenotypic plasticity can be critical to rapid acclimation. Epigenetic markers like DNA methylation are hypothesized as mediators of plasticity; methylation is associated with the regulation of gene expression, can change in response to ecological cues, and is a proposed basis for the inheritance of acquired traits. Within reef-building corals, gene-body methylation (gbM) can change in response to ecological stressors. If coral DNA methylation is transmissible across generations, this could potentially facilitate rapid acclimation to environmental change. We investigated methylation heritability in Acropora, a stony reef-building coral. Two Acropora millepora and two Acropora selago adults were crossed, producing eight offspring crosses (four hybrid, two of each species). We used whole-genome bisulfite sequencing to identify methylated loci and allele-specific alignments to quantify per-locus inheritance. If methylation is heritable, differential methylation (DM) between the parents should equal DM between paired offspring alleles at a given locus. We found a mixture of heritable and nonheritable loci, with heritable portions ranging from 44% to 90% among crosses. gBM was more heritable than intergenic methylation, and most loci had a consistent degree of heritability between crosses (i.e. the deviation between parental and offspring DM were of similar magnitude and direction). Our results provide evidence that coral methylation can be inherited but that heritability is heterogenous throughout the genome. Future investigations into this heterogeneity and its phenotypic implications will be important to understanding the potential capability of intergenerational environmental acclimation in reef building corals.
英文关键词	methylation; coral; epigenetic inheritance
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号	WOS:001157228800001
来源期刊	MOLECULAR BIOLOGY AND EVOLUTION
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/288969
作者单位	University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
推荐引用方式 GB/T 7714	Peterson, Christopher R.,Scott, Carly B.,Ghaffari, Rashin,et al. Mixed Patterns of Intergenerational DNA Methylation Inheritance in Acropora[J],2024,41(2).
APA	Peterson, Christopher R.,Scott, Carly B.,Ghaffari, Rashin,Dixon, Groves,&Matz, Mikhail, V.(2024).Mixed Patterns of Intergenerational DNA Methylation Inheritance in Acropora.MOLECULAR BIOLOGY AND EVOLUTION,41(2).
MLA	Peterson, Christopher R.,et al."Mixed Patterns of Intergenerational DNA Methylation Inheritance in Acropora".MOLECULAR BIOLOGY AND EVOLUTION 41.2(2024).