气候变化领域集成服务门户(CCPortal): Comparative skin histological and transcriptomic analysis of Rana kukunoris with two different skin colors

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DOI	10.1016/j.cbd.2024.101217
	Comparative skin histological and transcriptomic analysis of Rana kukunoris with two different skin colors
	Zhang, Xu-Ze; Ma, Xiao-Dong; Wang, Wan-Ting; Peng, Fei; Hou, Ye-Mao; Shen, Yue-Xia; Sun, Yu-Qi; Chen, Jin-Fang; Yin, Yi-Jin; Zeng, Yu-Ye; Yu, Yi; Zhou, Peng; Zhang, Fu-Hao; He, Yan-Feng; Shen, Ying-Fang
发表日期	2024
ISSN	1744-117X
EISSN	1878-0407
起始页码	50
卷号	50
英文摘要	This study compares the skin structures of Rana kukunoris with two different skin colors living in the same area of Haibei in the Northeastern Qinghai-Tibet Plateau. The skin thickness of the khaki R. kukunoris was significantly greater than that of the brown R. kukunoris (P < 0.01), and significantly more mucous and granular glands were present on the dorsal skin of the khaki frog (P < 0.05). Meanwhile, the melanocytes on the dorsal skin of the brown frog were significantly larger than those on the khaki one (P < 0.05). Morphological changes in the expansion and aggregation of melanocytes seemed to deepen the skin color of R. kukunoris. Moreover, transcriptome sequencing identified tyrosine metabolism, melanogenesis, and riboflavin metabolism as the main pathways involved in melanin formation and metabolism in brown R. kukunoris. TYR, MC1R was upregulated as the skin color of R. kukunoris was deepened and contributed to melanin production and metabolism. In contrast, the khaki frog had significantly more upregulated genes and metabolic pathways related to autoimmunity. The khaki frog appeared to defend against ultraviolet (UV) radiation-induced damage by secreting mucus and small molecular peptides, whereas the brown frog protected itself by distributing a large amount of melanin. Hence, the different skin colors of R. kukunoris might represent different adaptation strategies for survival in the intense UV radiation environment of the Qinghai-Tibet Plateau.
英文关键词	Rana kukunoris; UV -B radiation; Skin morphology; Transcriptomics; Melanin
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号	WOS:001194085900001
来源期刊	COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/288480
推荐引用方式 GB/T 7714	Zhang, Xu-Ze,Ma, Xiao-Dong,Wang, Wan-Ting,et al. Comparative skin histological and transcriptomic analysis of Rana kukunoris with two different skin colors[J],2024,50.
APA	Zhang, Xu-Ze.,Ma, Xiao-Dong.,Wang, Wan-Ting.,Peng, Fei.,Hou, Ye-Mao.,...&Shen, Ying-Fang.(2024).Comparative skin histological and transcriptomic analysis of Rana kukunoris with two different skin colors.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,50.
MLA	Zhang, Xu-Ze,et al."Comparative skin histological and transcriptomic analysis of Rana kukunoris with two different skin colors".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 50(2024).