气候变化领域集成服务门户(CCPortal): Gut microbiota modulation enhances the immune capacity of lizards under climate warming

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DOI	10.1186/s40168-023-01736-2
	Gut microbiota modulation enhances the immune capacity of lizards under climate warming
	Yang, Jing; Liu, Weiqiang; Han, Xingzhi; Hao, Xin; Yao, Qibin; Du, Weiguo
发表日期	2024
ISSN	2049-2618
起始页码	12
结束页码	1
卷号	12 期号:1
英文摘要	BackgroundHost-microbial interactions are expected to affect species' adaptability to climate change but have rarely been explored in ectothermic animals. Some studies have shown that short-term warming reduced gut microbial diversity that could hamper host functional performance.ResultsHowever, our longitudinal experiments in semi-natural conditions demonstrated that warming decreased gut microbiota diversity at 2 months, but increased diversity at 13 and 27 months in a desert lizard (Eremias multiocellata). Simultaneously, long-term warming significantly increased the antibacterial activity of serum, immune responses (higher expression of intestinal immune-related genes), and the concentration of short-chain fatty acids (thereby intestinal barrier and immunity) in the lizard. Fecal microbiota transplant experiments further revealed that increased diversity of gut microbiota significantly enhanced antibacterial activity and the immune response of lizards. More specifically, the enhanced immunity is likely due to the higher relative abundance of Bacteroides in warming lizards, given that the bacteria of Bacteroides fragilis regulated IFN-beta expression to increase the immune response of lizards under a warming climate.ConclusionsOur study suggests that gut microbiota can help ectotherms cope with climate warming by enhancing host immune response, and highlights the importance of long-term studies on host-microbial interactions and their biological impacts.Graphical Abstract6GDSteHzeFBZdjTKmE1qYrVideo Abstract
英文关键词	Climate change; Intestinal microflora; Immune capacity; Microbial symbiont; Reptile; Temperature
语种	英语
WOS研究方向	Microbiology
WOS类目	Microbiology
WOS记录号	WOS:001169818300001
来源期刊	MICROBIOME
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/287935
作者单位	Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Northeast Forestry University - China; Hainan University
推荐引用方式 GB/T 7714	Yang, Jing,Liu, Weiqiang,Han, Xingzhi,et al. Gut microbiota modulation enhances the immune capacity of lizards under climate warming[J],2024,12(1).
APA	Yang, Jing,Liu, Weiqiang,Han, Xingzhi,Hao, Xin,Yao, Qibin,&Du, Weiguo.(2024).Gut microbiota modulation enhances the immune capacity of lizards under climate warming.MICROBIOME,12(1).
MLA	Yang, Jing,et al."Gut microbiota modulation enhances the immune capacity of lizards under climate warming".MICROBIOME 12.1(2024).