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| DOI | 10.3390/cells13030269 |
| Effects of Temperature Adaptation on the Metabolism and Physiological Properties of Sturgeon Fish Larvae Cell Line | |
| 发表日期 | 2024 |
| EISSN | 2073-4409 |
| 起始页码 | 13 |
| 结束页码 | 3 |
| 卷号 | 13期号:3 |
| 英文摘要 | This study investigated how Atlantic sturgeon cells respond to elevated temperatures, shedding light on the potential impacts of climate change on fish. Atlantic sturgeon (Acipenser oxyrinchus), an IUCN (International Union for Conservation of Nature) Red List species and evolutionarily related to paleonisiform species, may have considerable physiological adaptability, suggesting that this species may be able to cope with changing climatic conditions and higher temperatures. To test this hypothesis, the AOXlar7y cell line was examined at 20 degrees C (control) and at elevated temperatures of 25 degrees C and 28 degrees C. Parameters including proliferation, vitality, morphology, and gene expressions related to proliferation, stemness, and stress were evaluated. Additionally, to achieve a comprehensive understanding of cellular changes, mitochondrial and metabolic activities were assessed using Seahorse XF96. AOXlar7y cells adapted to 28 degrees C exhibited enhanced mitochondrial adaptability, plasticity, heightened cell proliferation, and increased hsp70 expression. Increased baseline respiration indicated elevated ATP demand, which is potentially linked to higher cell proliferation and heat stress defense. Cells at 28 degrees C also displayed elevated reserve respiration capacity, suggesting adaptation to energy demands. At 25 degrees C, AOXlar7y cells showed no changes in basal respiration or mitochondrial capacity, suggesting unchanged ATP demand compared to cells cultivated at 20 degrees C. Proliferation and glycolytic response to energy requirements were diminished, implying a connection between glycolysis inhibition and proliferation suppression. These research results indicate sturgeon cells are capable of withstanding and adapting to an 8 degrees C temperature increase. This cellular analysis lays a foundation for future studies aimed at a deeper understanding of fish cell physiological adaptations, which will contribute to a better knowledge of environmental threats facing Atlantic sturgeon and fish populations amid climate change. |
| 英文关键词 | Acipenser oxyrinchus; climate change; temperature increase; heat shock; Seahorse XF96; fish cell line |
| 语种 | 英语 |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| WOS记录号 | WOS:001160289000001 |
| 来源期刊 | CELLS
 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/287213 |
| 作者单位 | Forschungsinstitut fur Nutztierbiologie (FBN); Greifswald Medical School; Forschungsinstitut fur Nutztierbiologie (FBN); Greifswald Medical School |
| 推荐引用方式 GB/T 7714 | . Effects of Temperature Adaptation on the Metabolism and Physiological Properties of Sturgeon Fish Larvae Cell Line[J],2024,13(3). |
| APA | (2024).Effects of Temperature Adaptation on the Metabolism and Physiological Properties of Sturgeon Fish Larvae Cell Line.CELLS,13(3). |
| MLA | "Effects of Temperature Adaptation on the Metabolism and Physiological Properties of Sturgeon Fish Larvae Cell Line".CELLS 13.3(2024). |
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