气候变化领域集成服务门户(CCPortal): Human genetic history on the Tibetan Plateau in the past 5100 years

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DOI	10.1126/sciadv.add5582
	Human genetic history on the Tibetan Plateau in the past 5100 years
	Wang, Hongru; Yang, Melinda A.; Wangdue, Shargan; Lu, Hongliang; Chen, Honghai; Li, Linhui; Dong, Guanghui; Tsring, Tinley; Yuan, Haibing; He, Wei; Ding, Manyu; Wu, Xiaohong; Li, Shuai; Tashi, Norbu; Yang, Tsho; Yang, Feng; Tong, Yan; Chen, Zujun; He, Yuanhong; Cao, Peng; Dai, Qingyan; Liu, Feng; Feng, Xiaotian; Wang, Tianyi; Yang, Ruowei; Ping, Wanjing; Zhang, Zhaoxia; Gao, Yang; Zhang, Ming; Wang, Xiaoji; Zhang, Chao; Yuan, Kai; Ko, Albert Min-Shan; Aldenderfer, Mark; Gao, Xing; Xu, Shuhua; Fu, Qiaomei
发表日期	2023
ISSN	2375-2548
卷号	9 期号:11
英文摘要	Using genome-wide data of 89 ancient individuals dated to 5100 to 100 years before the present (B.P.) from 29 sites across the Tibetan Plateau, we found plateau-specific ancestry across plateau populations, with substantial genetic structure indicating high differentiation before 2500 B.P. Northeastern plateau populations rapidly showed admixture associated with millet farmers by 4700 B.P. in the Gonghe Basin. High genetic similarity on the southern and southwestern plateau showed population expansion along the Yarlung Tsangpo River since 3400 years ago. Central and southeastern plateau populations revealed extensive genetic admixture within the plateau historically, with substantial ancestry related to that found in southern and southwestern plateau populations. Over the past similar to 700 years, substantial gene flow from lowland East Asia further shaped the genetic landscape of present-day plateau populations. The high-altitude adaptive EPAS1 allele was found in plateau populations as early as in a 5100-year-old individual and showed a sharp increase over the past 2800 years.
英文关键词	PERMANENT HUMAN OCCUPATION; ANCIENT HUMAN GENOMES; SKIN PIGMENTATION; HUMAN SETTLEMENT; HUMAN-EVOLUTION; EYE COLOR; SEQUENCE; HAIR; VARIANT; IDENTIFICATION
WOS研究方向	Multidisciplinary Sciences
WOS记录号	WOS:000969832000005
来源期刊	SCIENCE ADVANCES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283920
作者单位	Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; University of Richmond; Sichuan University; Sichuan University; Northwest University Xi'an; Lanzhou University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Peking University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; University of California System; University of California Merced; Fudan University; Fudan University; Fudan University; Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS
推荐引用方式 GB/T 7714	Wang, Hongru,Yang, Melinda A.,Wangdue, Shargan,et al. Human genetic history on the Tibetan Plateau in the past 5100 years[J],2023,9(11).
APA	Wang, Hongru.,Yang, Melinda A..,Wangdue, Shargan.,Lu, Hongliang.,Chen, Honghai.,...&Fu, Qiaomei.(2023).Human genetic history on the Tibetan Plateau in the past 5100 years.SCIENCE ADVANCES,9(11).
MLA	Wang, Hongru,et al."Human genetic history on the Tibetan Plateau in the past 5100 years".SCIENCE ADVANCES 9.11(2023).