气候变化领域集成服务门户(CCPortal): Gut microbiota and metabolic modulation by supplementation of polysaccharide-producing Bacillus licheniformis from Tibetan Yaks: A comprehensive multi-omics analysis

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DOI	10.1016/j.ijbiomac.2023.127808
	Gut microbiota and metabolic modulation by supplementation of polysaccharide-producing Bacillus licheniformis from Tibetan Yaks: A comprehensive multi-omics analysis
	Zeng, Zhibo; Quan, Chuxian; Zhou, Shimeng; Gong, Saisai; Iqbal, Mudassar; Kulyar, Muhammad Fakhar-e-Alam; Nawaz, Shah; Li, Kewei; Li, Jiakui
发表日期	2024
ISSN	0141-8130
EISSN	1879-0003
卷号	254
英文摘要	Gut microbiota and their metabolic processes depend on the intricate interplay of gut microbiota and their metabolic processes. Bacillus licheniformis, a beneficial food supplement, has shown promising effects on stabilizing gut microbiota and metabolites. However, the precise mechanisms underlying these effects remain elusive. In this study, we investigated the impact of polysaccharide-producing B. licheniformis as a dietary supplement on the gut microbiome and metabolites through a combination of scanning electron microscopy (SEM), histological analysis, high-throughput sequencing (HTS), and metabolomics. Our findings revealed that the B. licheniformistreated group exhibited significantly increased jejunal goblet cells. Moreover, gut microbial diversity was lower in the treatment group as compared to the control, accompanied by noteworthy shifts in the abundance of specific bacterial taxa. Enrichment of Firmicutes, Lachnospiraceae, and Clostridiales_bacterium contrasted with reduced levels of Campylobacterota, Proteobacteria, Parasutterella, and Helicobacter. Notably, the treatment group showed significant weight gain after 33 days, emphasizing the polysaccharide's impact on host metabolism. Delving into gut metabolomics, we discovered significant alterations in metabolites. Nine metabolites, including olprinone, pyruvic acid, and 2-methyl-3-oxopropanoate, were upregulated, while eleven, including defoslimod and voclosporin were down-regulated, shedding light on phenylpropanoid biosynthesis, tricarboxylic acid cycle (TCA cycle), and the glucagon signaling pathway. This comprehensive multi-omics analysis offers compelling insights into the potential of B. licheniformis as a dietary polysaccharide supplement for gut health and host metabolism, promising significant implications for gut-related issues.
关键词	Bacillus licheniformis Gut microbiome High -throughput sequencing Metabolomics Multi-omics analysis
英文关键词	REVEALS; OBESITY
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:001112374200001
来源期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283866
作者单位	Huazhong Agricultural University; Tibet Agriculture & Animal Husbandry University; Swiss Federal Institutes of Technology Domain; ETH Zurich; Islamia University of Bahawalpur
推荐引用方式 GB/T 7714	Zeng, Zhibo,Quan, Chuxian,Zhou, Shimeng,et al. Gut microbiota and metabolic modulation by supplementation of polysaccharide-producing Bacillus licheniformis from Tibetan Yaks: A comprehensive multi-omics analysis[J],2024,254.
APA	Zeng, Zhibo.,Quan, Chuxian.,Zhou, Shimeng.,Gong, Saisai.,Iqbal, Mudassar.,...&Li, Jiakui.(2024).Gut microbiota and metabolic modulation by supplementation of polysaccharide-producing Bacillus licheniformis from Tibetan Yaks: A comprehensive multi-omics analysis.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,254.
MLA	Zeng, Zhibo,et al."Gut microbiota and metabolic modulation by supplementation of polysaccharide-producing Bacillus licheniformis from Tibetan Yaks: A comprehensive multi-omics analysis".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 254(2024).