气候变化领域集成服务门户(CCPortal): Tibetan highland barley fiber improves obesity and regulates gut microbiota in high-fat diet-fed mice

CCPortal

DOI	10.1016/j.fbio.2023.102620
	Tibetan highland barley fiber improves obesity and regulates gut microbiota in high-fat diet-fed mice
	Gan, Linyao; Han, Jing; Li, Chenyao; Tang, Jing; Wang, Xuebing; Ma, Yue; Chen, Yefu; Xiao, Dongguang; Guo, Xuewu
发表日期	2023
ISSN	2212-4292
EISSN	2212-4306
卷号	53
英文摘要	Tibetan highland barley fiber (T-Fiber) contains high dietary fiber (DF) and beta-glucose. Highland barley has been shown to reduce the risk of diseases associated with high-fat diets (HFD). In the present research, we studied whether T-Fiber could ameliorate HFD-induced obesity in mice and explored its regulatory effects on intestinal microbes. Our findings revealed that T-Fiber feeding significantly reduced weight gain and dyslipi-demia, improved glucose tolerance and insulin resistance, alleviated chronic systemic inflammation, and increased short-chain fatty acids (SCFA) in feces in mice. Histological observations confirmed that T-Fiber alleviated Epididymal fat (EF) and lipid accumulation in the liver. In addition, 16s rRNA sequencing analysis of mice cecum contents showed that T-Fiber restored the HFD-induced gut microbiota. T-Fiber supplementation increased the abundance of potentially beneficial bacteria Muribaculaceae, Akkermansiaceae, and Lachnospir-aceae_NK4A136_groups, while significantly reducing the abundance of Bacteroidaceae, Prevotellaceae, Rikenella-ceae, and Alloprevotella. Furthermore, the increase in the production of SCFA may be related to the abundance of Lachnospiraceae_NK4A136_group. In conclusion, T-Fiber has some anti-obesity abilities under high-fat feeding and can be developed as a relevant anti-obesity product.
关键词	Gut microbiota Highland barley Fiber Obesity C57BL 6J mice
英文关键词	BENEFITS; QINGKE
WOS研究方向	Food Science & Technology
WOS记录号	WOS:000980094500001
来源期刊	FOOD BIOSCIENCE
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283831
作者单位	Tianjin University Science & Technology
推荐引用方式 GB/T 7714	Gan, Linyao,Han, Jing,Li, Chenyao,et al. Tibetan highland barley fiber improves obesity and regulates gut microbiota in high-fat diet-fed mice[J],2023,53.
APA	Gan, Linyao.,Han, Jing.,Li, Chenyao.,Tang, Jing.,Wang, Xuebing.,...&Guo, Xuewu.(2023).Tibetan highland barley fiber improves obesity and regulates gut microbiota in high-fat diet-fed mice.FOOD BIOSCIENCE,53.
MLA	Gan, Linyao,et al."Tibetan highland barley fiber improves obesity and regulates gut microbiota in high-fat diet-fed mice".FOOD BIOSCIENCE 53(2023).