气候变化领域集成服务门户(CCPortal): Genetic Origins and Adaptive Evolution of the Deng People on the Tibetan Plateau

CCPortal

DOI	10.1093/molbev/msad205
	Genetic Origins and Adaptive Evolution of the Deng People on the Tibetan Plateau
	Ge, Xueling; Lu, Yan; Chen, Shuanghui; Gao, Yang; Ma, Lifeng; Liu, Lijun; Liu, Jiaojiao; Ma, Xixian; Kang, Longli; Xu, Shuhua
发表日期	2023
ISSN	0737-4038
EISSN	1537-1719
卷号	40 期号:10
英文摘要	The Tibetan Plateau is populated by diverse ethnic groups, but most of them are underrepresented in genomics studies compared with the Tibetans (TIB). Here, to gain further insight into the genetic diversity and evolutionary history of the people living in the Tibetan Plateau, we sequenced 54 whole genomes of the Deng people with high coverage (30-60x) and analyzed the data together with that of TIB and Sherpas, as well as 968 ancient Asian genomes and available archaic and modern human data. We identified 17.74 million novel single-nucleotide variants from the newly sequenced genomes, although the Deng people showed reduced genomic diversity and a relatively small effective population size. Compared with the other Tibetan highlander groups which are highly admixed, the Deng people are dominated by a sole ancestry that could be traced to some ancient northern East Asian populations. The divergence between Deng and Tibetan people (similar to 4,700-7,200 years) was more recent than that between highlanders and the Han Chinese (Deng-HAN, similar to 9,000-14,000 years; TIB-HAN, 7,200-10,000 years). Adaptive genetic variants (AGVs) identified in the Deng are only partially shared with those previously reported in the TIB like HLA-DQB1, whereas others like KLHL12 were not reported in TIB. In contrast, the top candidate genes harboring AGVs as previously identified in TIB, like EPAS1 and EGLN1, do not show strong positive selection signals in Deng. Interestingly, Deng also showed a different archaic introgression scenario from that observed in the TIB. Our results suggest that convergent adaptation might be prevalent on the Tibetan Plateau.
关键词	Tibetan altitudinal adaptation next-generation sequencing archaic ancestry Denisovan Neanderthal
英文关键词	GENOME SEQUENCE; ALTITUDE ADAPTATION; FRAMEWORK; POPULATIONS; HISTORY; ROUTES
WOS研究方向	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号	WOS:001085518300005
来源期刊	MOLECULAR BIOLOGY AND EVOLUTION
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283830
作者单位	Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Fudan University; ShanghaiTech University; Xizang Minzu University; Xizang Minzu University; Fudan University; Fudan University
推荐引用方式 GB/T 7714	Ge, Xueling,Lu, Yan,Chen, Shuanghui,et al. Genetic Origins and Adaptive Evolution of the Deng People on the Tibetan Plateau[J],2023,40(10).
APA	Ge, Xueling.,Lu, Yan.,Chen, Shuanghui.,Gao, Yang.,Ma, Lifeng.,...&Xu, Shuhua.(2023).Genetic Origins and Adaptive Evolution of the Deng People on the Tibetan Plateau.MOLECULAR BIOLOGY AND EVOLUTION,40(10).
MLA	Ge, Xueling,et al."Genetic Origins and Adaptive Evolution of the Deng People on the Tibetan Plateau".MOLECULAR BIOLOGY AND EVOLUTION 40.10(2023).