气候变化领域集成服务门户(CCPortal): Population genomics analysis to identify ion and water transporter genes involved in the adaptation of Tibetan naked carps to brackish water

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DOI	10.1016/j.ijbiomac.2023.125605
	Population genomics analysis to identify ion and water transporter genes involved in the adaptation of Tibetan naked carps to brackish water
	Tian, Fei; Zhou, Bingzheng; Li, Xiaohuan; Zhang, Yu; Qi, Delin; Qi, Hongfang; Jiang, Huamin; Zhao, Kai; Liu, Sijia
发表日期	2023
ISSN	0141-8130
EISSN	1879-0003
卷号	247
英文摘要	Understanding how evolutionary processes shape the genetic variations and influence the response of species to environmental alterations is critical for biodiversity conservation and molecular breeding. Gymnocypris prze-walskii przewalskii is the only known cyprinid fish that dwells in the brackish water of Lake Qinghai on the Qinghai-Tibetan Plateau. To reveal the genetic basis of its adaptation to high salinity and alkalinity, whole-genome sequencing was performed in G. p. przewalskii and its freshwater relatives Gymnocypris eckloni and Gymnocypris przewalskii ganzihonensis. Compared with freshwater species, lower genetic diversity and higher linkage disequilibrium were observed in G. p. przewalskii. Selective sweep analysis identified 424 core-selective genes enriched in transport activities. Transfection analysis showed that genetic changes in the positively selected gene aquaporin 3 (AQP3) improved cell viability after salt treatment, suggesting its involvement in brackish water adaptation. Our analysis indicates that ion and water transporter genes experienced intensive selection, which might have contributed to the maintenance of high osmolality and ion content in G. p. prze-walskii. The current study identified key molecules involved in the adaptation of fish to brackish water, providing valuable genomic resources for the molecular breeding of salt-tolerant fish.
关键词	Adaptation Gymnocypris przewalskii Resequencing Selective sweeps Aquaporin 3 Cell viability
英文关键词	EEL ANGUILLA-ANGUILLA; GYMNOCYPRIS-PRZEWALSKII; ADAPTIVE EVOLUTION; OSMOREGULATORY TISSUES; STATISTICAL TESTS; LAKE QINGHAI; AQUAPORIN-3; EXPRESSION; DIVERGENCE; NEUTRALITY
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS记录号	WOS:001048763400001
来源期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283824
作者单位	Chinese Academy of Sciences; Qinghai University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences
推荐引用方式 GB/T 7714	Tian, Fei,Zhou, Bingzheng,Li, Xiaohuan,et al. Population genomics analysis to identify ion and water transporter genes involved in the adaptation of Tibetan naked carps to brackish water[J],2023,247.
APA	Tian, Fei.,Zhou, Bingzheng.,Li, Xiaohuan.,Zhang, Yu.,Qi, Delin.,...&Liu, Sijia.(2023).Population genomics analysis to identify ion and water transporter genes involved in the adaptation of Tibetan naked carps to brackish water.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,247.
MLA	Tian, Fei,et al."Population genomics analysis to identify ion and water transporter genes involved in the adaptation of Tibetan naked carps to brackish water".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 247(2023).