气候变化领域集成服务门户(CCPortal): Integrated biomarker profiling of the metabolome associated with type 2 diabetes mellitus among Tibetan in China

CCPortal

DOI	10.1186/s13098-023-01124-8
	Integrated biomarker profiling of the metabolome associated with type 2 diabetes mellitus among Tibetan in China
	Meng, Jinli; Huang, Fangfang; Shi, Jing; Zhang, Chenghui; Feng, Li; Wang, Suyuan; Li, Hengyan; Guo, Yongyue; Hu, Xin; Li, Xiaomei; He, Wanlin; Cheng, Jian; Wu, Yunhong
发表日期	2023
EISSN	1758-5996
卷号	15 期号:1
英文摘要	IntroductionMetabolomic signatures of type 2 diabetes mellitus (T2DM) in Tibetan Chinese population, a group with high diabetes burden, remain largely unclear. Identifying the serum metabolite profile of Tibetan T2DM (T-T2DM) individuals may provide novel insights into early T2DM diagnosis and intervention.MethodsHence, we conducted untargeted metabolomics analysis of plasma samples from a retrospective cohort study with 100 healthy controls and 100 T-T2DM patients by using liquid chromatography-mass spectrometry.ResultsThe T-T2DM group had significant metabolic alterations that are distinct from known diabetes risk indicators, such as body mass index, fasting plasma glucose, and glycosylated hemoglobin levels. The optimal metabolite panels for predicting T-T2DM were selected using a tenfold cross-validation random forest classification model. Compared with the clinical features, the metabolite prediction model provided a better predictive value. We also analyzed the correlation of metabolites with clinical indices and found 10 metabolites that were independently predictive of T-T2DM.ConclusionBy using the metabolites identified in this study, we may provide stable and accurate biomarkers for early T-T2DM warning and diagnosis. Our study also provides a rich and open-access data resource for optimizing T-T2DM management.
关键词	Tibetan Type 2 diabetes mellitus Serum metabolomics Machine learning Biomarker
英文关键词	SERUM URIC-ACID; INSULIN-RESISTANCE; FASTING GLUCOSE; PLASMA-GLUCOSE; PREVALENCE; RISK; PROGRESSION; MARKERS; HEALTH
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001021019200001
来源期刊	DIABETOLOGY & METABOLIC SYNDROME
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283801
作者单位	Hubei University of Chinese Medicine; Sichuan University
推荐引用方式 GB/T 7714	Meng, Jinli,Huang, Fangfang,Shi, Jing,et al. Integrated biomarker profiling of the metabolome associated with type 2 diabetes mellitus among Tibetan in China[J],2023,15(1).
APA	Meng, Jinli.,Huang, Fangfang.,Shi, Jing.,Zhang, Chenghui.,Feng, Li.,...&Wu, Yunhong.(2023).Integrated biomarker profiling of the metabolome associated with type 2 diabetes mellitus among Tibetan in China.DIABETOLOGY & METABOLIC SYNDROME,15(1).
MLA	Meng, Jinli,et al."Integrated biomarker profiling of the metabolome associated with type 2 diabetes mellitus among Tibetan in China".DIABETOLOGY & METABOLIC SYNDROME 15.1(2023).