气候变化领域集成服务门户(CCPortal): Brain Structural and Functional Alterations in Native Tibetans Living at High Altitude

CCPortal

DOI	10.1016/j.neuroscience.2023.01.019
	Brain Structural and Functional Alterations in Native Tibetans Living at High Altitude
	Zhang, Xinjuan; Xie, Weiwei; Liu, Yanqiu; Li, Minglu; Lin, Jianzhong; Yin, Wu; Yang, Lihui; Li, Pengji; Sun, Ying; Li, Tianzhi; Liu, Haipeng; Ma, Hailin; Zhang, Jiaxing
发表日期	2023
ISSN	0306-4522
EISSN	1873-7544
起始页码	134
结束页码	143
卷号	520
英文摘要	have adapted to high altitude environments. However, the genetic effects in their brains have not been identified. Twenty-five native Tibetans living in Lhasa (3650 m) were recruited for comparison with 20 Han immigrants who originated from lowlands and had been living in Lhasa for two years. The physiological char-acteristics, brain structure and neuronal spontaneous activity were investigated. Compared with Han immigrants, Tibetans showed higher peripheral oxygen saturation (SpO2), and lower heart rate, red blood cell counts, hema-tocrit, and hemoglobin. Tibetans showed increased gray matter volume in the visual cortex, hippocampus, and rectus; increased the amplitudes of low-frequency fluctuations (ALFF) values in the left putamen and left fusiform gyrus; and decreased voxel-mirrored homotopic connectivity (VMHC) values in the precentral gyrus. Moreover, Tibetans have decreased functional connectivity (FC) between the left precentral gyrus and the frontal gyrusand right precuneus. In Tibetans and Han immigrants, hemoglobin and hematocrit were negatively correlated with total gray matter volume in males, SpO2 was also positively correlated with ALFF in the left fusiform gyrus, while hemoglobin, and hematocrit were positively correlated with VMHC in the precentral gyrus and FC in the precentral gyrus with other brain regions, SpO2 was also found to be negatively correlated with VMHC in the precentral gyrus, and hemoglobin and hematocrit were negatively correlated with ALFF in the left putamen and left fusiform gyrus. In summary, genetic mutations may result in modulation of some brain regions, which was further con-firmed by the identification of correlations with hemoglobin and hematocrit in these regions.& COPY; 2023 IBRO. Published by Elsevier Ltd. All rights reserved.
关键词	Tibetans brain structure spontaneous brain activity
英文关键词	RESTING-STATE; NEUROIMAGING CHANGES; HYPOXIA; ADAPTATION; CORTEX; LIFE
WOS研究方向	Neurosciences
WOS记录号	WOS:001013038700001
来源期刊	NEUROSCIENCE
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283800
作者单位	Xiamen University; Xiamen University; Tibet University; Xiamen University; Xiamen University
推荐引用方式 GB/T 7714	Zhang, Xinjuan,Xie, Weiwei,Liu, Yanqiu,et al. Brain Structural and Functional Alterations in Native Tibetans Living at High Altitude[J],2023,520.
APA	Zhang, Xinjuan.,Xie, Weiwei.,Liu, Yanqiu.,Li, Minglu.,Lin, Jianzhong.,...&Zhang, Jiaxing.(2023).Brain Structural and Functional Alterations in Native Tibetans Living at High Altitude.NEUROSCIENCE,520.
MLA	Zhang, Xinjuan,et al."Brain Structural and Functional Alterations in Native Tibetans Living at High Altitude".NEUROSCIENCE 520(2023).