气候变化领域集成服务门户(CCPortal): Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants

CCPortal

DOI	10.1007/s11682-023-00759-5
	Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants
	Zhang, Xinjuan; Xie, Weiwei; Du, Wenrui; Liu, Yanqiu; Lin, Jianzhong; Yin, Wu; Yang, Lihui; Yuan, Fengjuan; Zhang, Ran; Liu, Haipeng; Ma, Hailin; Zhang, Jiaxing
发表日期	2023
ISSN	1931-7557
EISSN	1931-7565
英文摘要	It has been well-established that high-altitude (HA) environments affect the human brain; however, the differences in brain structural and functional networks between HA natives and acclimatized immigrants have not been well clarified. In this study, native HA Tibetans were recruited for comparison with Han immigrants (average of 2.3 +/- 0.3 years at HA), with lowland residents recruited as controls. Cortical gray matter volume, thickness, and functional connectivity were investigated using magnetic resonance imaging data. In addition, reaction time and correct score in the visual movement task, hematology, and SpO(2) were measured. In both Tibetans and HA immigrants vs. lowlanders, decreased SpO(2), increased hematocrit and hemoglobin, and increased reaction time and correct score in the visual movement task were detected. In both Tibetans and HA immigrants vs. lowlanders, gray matter volumes and cortical thickness were increased in the left somatosensory and motor cortex, and functional connectivity was decreased in the visual, default mode, subcortical, somatosensory-motor, ventral attention, and subcortical networks. Furthermore, SpO(2) increased, hematocrit and hemoglobin decreased, and gray matter volumes and cortical thickness increased in the visual cortex, left motor cortex, and right auditory cortex in native Tibetans compared to immigrants. Movement time and correct score in task were positively correlated with the thickness of the visual cortex. In conclusion, brain structural and functional network difference in both Tibetan natives and HA immigrants were largely consistent, with native Tibetans only showing more intense brain modulation. Different populations acclimatized to HA develop similar brain mechanisms to cope with hostile HA environmental factors.
关键词	High altitude Tibetans Hypoxia Brain structure Brain functional networks
英文关键词	CORTICAL THICKNESS; ADAPTATION; ORGANIZATION; PERFORMANCE
WOS研究方向	Neuroimaging
WOS记录号	WOS:000917764000001
来源期刊	BRAIN IMAGING AND BEHAVIOR
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283795
作者单位	Xiamen University; Tibet University; Xiamen University; Xiamen University
推荐引用方式 GB/T 7714	Zhang, Xinjuan,Xie, Weiwei,Du, Wenrui,et al. Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants[J],2023.
APA	Zhang, Xinjuan.,Xie, Weiwei.,Du, Wenrui.,Liu, Yanqiu.,Lin, Jianzhong.,...&Zhang, Jiaxing.(2023).Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants.BRAIN IMAGING AND BEHAVIOR.
MLA	Zhang, Xinjuan,et al."Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants".BRAIN IMAGING AND BEHAVIOR (2023).