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Transcriptome analysis reveals molecular pathways in the iron-overloaded Tibetan population | |
Zhao, Qin; Hao, Doudou; Chen, Siyuan; Wang, Siyu; Zhou, Chaohua; Shi, Jing; Wan, Sha; Zhang, Yongqun; He, Zeng | |
发表日期 | 2023 |
ISSN | 0918-8959 |
EISSN | 1348-4540 |
起始页码 | 185 |
结束页码 | 196 |
卷号 | 70期号:2 |
英文摘要 | Iron overload can lead to chronic complications, serious organ dysfunction or death in the body. Under hypoxic conditions, the body needs more iron to produce red blood cells to adapt to the hypoxic environment. The prevalence of iron overload in the Tibetan population is higher than that in the Han population. To explore the molecular mechanism of iron -overload in the Tibetan population, this study investigated the transcriptome of the Tibetan iron overload population to obtain differentially expressed genes (DEGs) between the iron-overloaded population and the normal iron population. Functional enrichment analysis identified key related pathways, gene modules and coexpression networks under iron-overload conditions, and the 4 genes screened out have the potential to become target genes for studying the development of iron overload. A total of 28 pathways were screened to be closely related to the occurrence and development of iron overload, showing that iron overload is extremely related to erythrocyte homeostasis, cell cycle, oxidative phosphorylation, immunity, and transcriptional repression. |
关键词 | TranscriptomeTibetansIron overloadFunctional enrichment analysis |
英文关键词 | INFLAMMATION; HOMEOSTASIS; CHROMIUM; FERRITIN; OBESITY; RATS |
WOS研究方向 | Endocrinology & Metabolism |
WOS记录号 | WOS:000938591600007 |
来源期刊 | ENDOCRINE JOURNAL
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文献类型 | 期刊论文 |
条目标识符 | http://gcip.llas.ac.cn/handle/2XKMVOVA/283786 |
推荐引用方式 GB/T 7714 | Zhao, Qin,Hao, Doudou,Chen, Siyuan,et al. Transcriptome analysis reveals molecular pathways in the iron-overloaded Tibetan population[J],2023,70(2). |
APA | Zhao, Qin.,Hao, Doudou.,Chen, Siyuan.,Wang, Siyu.,Zhou, Chaohua.,...&He, Zeng.(2023).Transcriptome analysis reveals molecular pathways in the iron-overloaded Tibetan population.ENDOCRINE JOURNAL,70(2). |
MLA | Zhao, Qin,et al."Transcriptome analysis reveals molecular pathways in the iron-overloaded Tibetan population".ENDOCRINE JOURNAL 70.2(2023). |
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