气候变化领域集成服务门户(CCPortal): Serum metabolomics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau has unique characteristics

CCPortal

DOI	10.1038/s41598-023-40027-6
	Serum metabolomics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau has unique characteristics
	Zhang, Heng; Ma, Xianzong; Xu, Junfeng; Jin, Peng; Yang, Lang; Pan, Yuanming; Yin, Fumei; Zhang, Jie; Wang, Jiheng; Yu, Dongliang; Wang, Xiaoying; Zhang, Mingjie; Wang, Xin; Wang, Dezhi; Sheng, Jianqiu
发表日期	2023
ISSN	2045-2322
卷号	13 期号:1
英文摘要	Few studies have provided data on the metabolomics characteristics of metabolic diseases such as hyperuricemia and hyperbilirubinemia in the Tibetan plateau. In the current study, we sought to investigate the serum metabolomics characteristics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau, with the aim to provide a basis for further research on their pathogenesis, prevention, and treatment. The study participants were born in low-altitude areas below 1000 m and had no prior experience living in a high-altitude area before entering Golmud, Tibet (average elevation: 3000 m) and Yushu, Qinghai (average elevation: 4200 m). Thirty-four participants with hyperbilirubinemia (18 in Golmud and 16 in Yushu), 24 participants with hyperuricemia, and 22 healthy controls were enrolled. The serum samples of subjects were separated and then sent to a local tertiary hospital for biochemical examination. Serum widely targeted technology, based on the ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) platform, was used to detect serum metabolites and differential metabolites. Compared to the healthy controls, hyperbilirubinemia patients from Golmud showed 19 differential metabolites, hyperbilirubinemia patients from Yushu showed 12 differential metabolites, and hyperuricemia patients from Yushu showed 23 differential metabolites. Compared to the hyperbilirubinemia patients from Golmud that is at a low altitude, the Yushu groups had 33 different metabolites. Differential metabolites are primarily classified into amino acids and their derivatives, nucleotides and their derivatives, organic acids and their derivatives, and lipids/fatty acids. These are related to metabolic pathways such as caffeine metabolism, arachidonic acid metabolism, and tyrosine metabolism. Hyperbilirubinemia and hyperuricemia in the Tibetan plateau have unique serum metabolomics characteristics. Glycine derivatives and arachidonic acid and its derivatives were associated with plateau hyperbilirubinemia, and vanillic acid and pentadecafluorooctanoic acid were associated with plateau hyperuricemia.
英文关键词	SMOOTH-MUSCLE-CELLS; VANILLIC ACID; OXIDATIVE STRESS; HIGH-ALTITUDE; DAMAGE; LIVER; BILIRUBIN; BRAIN; BLOOD; APOPTOSIS
WOS研究方向	Multidisciplinary Sciences
WOS记录号	WOS:001044365500009
来源期刊	SCIENTIFIC REPORTS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283746
作者单位	Chinese People's Liberation Army General Hospital; Seventh Medical Center of Chinese PLA General Hospital; Chinese People's Liberation Army General Hospital
推荐引用方式 GB/T 7714	Zhang, Heng,Ma, Xianzong,Xu, Junfeng,et al. Serum metabolomics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau has unique characteristics[J],2023,13(1).
APA	Zhang, Heng.,Ma, Xianzong.,Xu, Junfeng.,Jin, Peng.,Yang, Lang.,...&Sheng, Jianqiu.(2023).Serum metabolomics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau has unique characteristics.SCIENTIFIC REPORTS,13(1).
MLA	Zhang, Heng,et al."Serum metabolomics of hyperbilirubinemia and hyperuricemia in the Tibetan plateau has unique characteristics".SCIENTIFIC REPORTS 13.1(2023).