气候变化领域集成服务门户(CCPortal): Whole mitochondrial genome analysis in highland Tibetans: further matrilineal genetic structure exploration

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DOI	10.3389/fgene.2023.1221388
	Whole mitochondrial genome analysis in highland Tibetans: further matrilineal genetic structure exploration
	Li, Xin; Zhang, Xianpeng; Yu, Ting; Ye, Liping; Huang, Ting; Chen, Ying; Liu, Shuhan; Wen, Youfeng
发表日期	2023
EISSN	1664-8021
卷号	14
英文摘要	Introduction: The Qinghai-Tibet Plateau is one of the last terrestrial environments conquered by modern humans. Tibetans are among the few high-altitude settlers in the world, and understanding the genetic profile of Tibetans plays a pivotal role in studies of anthropology, genetics, and archaeology.Methods: In this study, we investigated the maternal genetic landscape of Tibetans based on the whole mitochondrial genome collected from 145 unrelated native Lhasa Tibetans. Molecular diversity indices, haplotype diversity (HD), Tajima's D and Fu's Fs were calculated and the Bayesian Skyline Plot was obtained to determining the genetic profile and population fluctuation of Lhasa Tibetans. To further explore the genetic structure of Lhasa Tibetans, we collected 107 East Asian reference populations to perform principal component analysis (PCA), multidimensional scaling (MDS), calculated Fst values and constructed phylogenetic tree.Results: The maternal genetic landscape of Tibetans showed obvious East Asian characteristics, M9a (28.28%), R (11.03%), F1 (12.41%), D4 (9.66%), N (6.21%), and M62 (4.14%) were the dominant haplogroups. The results of PCA, MDS, Fst and phylogenetic tree were consistent: Lhasa Tibetans clustered with other highland Tibeto-Burman speakers, there was obvious genetic homogeneity of Tibetans in Xizang, and genetic similarity between Tibetans and northern Han people and geographically adjacent populations was found. In addition, specific maternal lineages of Tibetans also be determined in this study.Discussion: In general, this study further shed light on long-time matrilineal continuity on the Tibetan Plateau and the genetic connection between Tibetans and millet famers in the Yellow River Basin, and further revealed that multiple waves of population interaction and admixture during different historical periods between lowland and highland populations shaped the maternal genetic profile of Tibetans.
关键词	Tibetan mtDNA haplogroup maternal genetic structure
英文关键词	HUMAN OCCUPATION; READ ALIGNMENT; POPULATION; PLATEAU; SEQUENCE; DNA; NORTHERN; SETTLEMENT; HISTORY; SUITE
WOS研究方向	Genetics & Heredity
WOS记录号	WOS:001108033300001
来源期刊	FRONTIERS IN GENETICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283739
作者单位	Jinzhou Medical University; Jinzhou Medical University
推荐引用方式 GB/T 7714	Li, Xin,Zhang, Xianpeng,Yu, Ting,et al. Whole mitochondrial genome analysis in highland Tibetans: further matrilineal genetic structure exploration[J],2023,14.
APA	Li, Xin.,Zhang, Xianpeng.,Yu, Ting.,Ye, Liping.,Huang, Ting.,...&Wen, Youfeng.(2023).Whole mitochondrial genome analysis in highland Tibetans: further matrilineal genetic structure exploration.FRONTIERS IN GENETICS,14.
MLA	Li, Xin,et al."Whole mitochondrial genome analysis in highland Tibetans: further matrilineal genetic structure exploration".FRONTIERS IN GENETICS 14(2023).