气候变化领域集成服务门户(CCPortal): Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens

CCPortal

DOI	10.1186/s12864-024-10030-w
	Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens
	Xue, Mingming; Yu, Runjie; Yang, Lixian; Xie, Fuyin; Fang, Meiying; Tang, Qiguo
发表日期	2024
ISSN	1471-2164
卷号	25 期号:1
英文摘要	BackgroundExploring the hypoxia adaptation mechanism of Tibetan chicken is of great significance for revealing the survival law of Tibetan chicken and plateau animal husbandry production. To investigate the hypoxia adaptation of Tibetan chickens (TBCs), an integrative metabolomic-transcriptomic analysis of the liver on day 18 of embryonic development was performed. Dwarf laying chickens (DLCs), a lowland breed, were used as a control.ResultsA total of 1,908 metabolites were identified in both TBCs and DLCs. Energy metabolism and amino acid metabolism related differentially regulated metabolites (DRMs) were significantly enriched under hypoxia. Important metabolic pathways including the TCA cycle and arginine and proline metabolism were screened; PCK1, SUCLA2, and CPS1 were found to be altered under hypoxic conditions. In addition, integrated analysis suggested potential differences in mitochondrial function, which may play a crucial role in the study of chicken oxygen adaptation.ConclusionsThese results suggest that hypoxia changed the gene expression and metabolic patterns of embryonic liver of TBCs compared to DLCs. Our study provides a basis for uncovering the molecular regulation mechanisms of hypoxia adaptation in TBCs with the potential application of hypoxia adaptation research for other animals living on the Qinghai-Tibet plateau, and may even contribute to the study of diseases caused by hypoxia.
关键词	Tibetan chickens Metabolomics Transcriptomics Embryonic liver Hypoxia
英文关键词	HIGH-ALTITUDE ADAPTATION; ENERGY-METABOLISM; SUCCINATE; SIGNAL
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:001155978400003
来源期刊	BMC GENOMICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283683
作者单位	China Agricultural University
推荐引用方式 GB/T 7714	Xue, Mingming,Yu, Runjie,Yang, Lixian,et al. Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens[J],2024,25(1).
APA	Xue, Mingming,Yu, Runjie,Yang, Lixian,Xie, Fuyin,Fang, Meiying,&Tang, Qiguo.(2024).Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens.BMC GENOMICS,25(1).
MLA	Xue, Mingming,et al."Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens".BMC GENOMICS 25.1(2024).