气候变化领域集成服务门户(CCPortal): Efficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial

CCPortal

DOI	10.1186/s12906-023-04328-7
	Efficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial
	Shang, Ya-xi; Wei, Shu-feng; Yang, Ke-peng; Liu, Yuan; Wei, Su; Dong, Xia; Wang, Xin-chang; Xie, Zhi-min; Fang, Ru-lu; Liang, Li-na; Li, Xiu-feng; Xu, Lei; Chen, Mu-zhi; Zhang, Kai-xian; Huang, Ji-yong; Wang, Le; Yang, You-guo; Liao, Hong-li; Xing, Gui-e; Zheng, Yu-ping; Li, Xiao-fen; Lin, Jing-lian; Shi, Cheng-qian; Zeng, Yong-ping; Mo, Li-dan; Sun, Fan; Li, Xiao-peng; Zhang, Zhuo; Chen, Kai; He, Zhao-chun; Liu, Jian-ping
发表日期	2024
EISSN	2662-7671
卷号	24 期号:1
英文摘要	BackgroundThis study aims to assess the efficacy and safety of Qingpeng ointment (QPO), a Tibetan medicine for alleviating symptoms in individuals with acute gouty arthritis (AGA).MethodsThis study was a randomized, double-blind, placebo-controlled trial that involved individuals with AGA whose joint pain, as measured on a visual analog scale (VAS) from 0 to 10, was equal to or greater than 3. The participants were randomly assigned to either the QPO or the placebo group and received their respective treatments twice daily for seven consecutive days. In case of intolerable pain, the participants were allowed to use diclofenac sodium sustained-release tablets as a rescue medicine. The primary outcomes measured were joint pain and swelling, while the secondary outcomes included joint mobility, redness, serum uric acid levels, C-reactive protein levels, and the amount of remaining rescue medicine. Any adverse events that occurred during the trial were also recorded.ResultsA total of 203 cases were divided into two groups, with balanced baselines: 102 in the QPO group and 101 in the placebo group. For joint pain, differences between the groups were notable in the VAS scores [1.75 (0, 3.00) versus 2.00 (1.00, 3.50); P = 0.038], changes in VAS [5.00 (3.00, 6.00) versus 4.00 (2.00, 6.00); P = 0.036], and disappearance rate [26.47% compared to 15.84%; P = 0.046] after treatment. Concerning joint swelling, significant between-group differences were observed in the VAS scores [1.00 (0, 2.30) versus 2.00 (0.70, 3.00); P = 0.032] and disappearance rate [33.33% compared to 21.78%; P = 0.046] at treatment completion. The QPO group exhibited a statistically significant mobility improvement compared to the placebo group (P = 0.004). No significant differences were found in other secondary outcomes. Five patients, four from the QPO group and one from the other, encountered mild adverse events, primarily skin irritation. All of these cases were resolved after dosage reduction or discontinuation of the medication.ConclusionsCompared to the placebo, QPO exhibits positive effects on AGA by alleviating pain, reducing swelling, and enhancing joint mobility, without causing significant adverse effects.Trial RegistrationISRCTN34355813. Registered on 25/01/2021.
关键词	Tibetan medicine Qingpeng ointment Acute gouty arthritis Randomized controlled trial Integrative medicine Pain
英文关键词	NONSTEROIDAL ANTIINFLAMMATORY DRUGS; AMERICAN-COLLEGE; PREVALENCE; EPIDEMIOLOGY; POPULATION; MANAGEMENT; RISK
WOS研究方向	Integrative & Complementary Medicine
WOS记录号	WOS:001136803800001
来源期刊	BMC COMPLEMENTARY MEDICINE AND THERAPIES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283676
作者单位	Beijing University of Chinese Medicine; Shaanxi University of Chinese Medicine; Beijing University of Chinese Medicine; Zhejiang Chinese Medical University; UiT The Arctic University of Tromso
推荐引用方式 GB/T 7714	Shang, Ya-xi,Wei, Shu-feng,Yang, Ke-peng,et al. Efficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial[J],2024,24(1).
APA	Shang, Ya-xi.,Wei, Shu-feng.,Yang, Ke-peng.,Liu, Yuan.,Wei, Su.,...&Liu, Jian-ping.(2024).Efficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial.BMC COMPLEMENTARY MEDICINE AND THERAPIES,24(1).
MLA	Shang, Ya-xi,et al."Efficacy of Qingpeng ointment (a Tibetan medicine) for acute gouty arthritis: a multi-center, randomized, double-blind, placebo-controlled trial".BMC COMPLEMENTARY MEDICINE AND THERAPIES 24.1(2024).