气候变化领域集成服务门户(CCPortal): A study on the correlation between hemoglobin concentration and the storage quality of suspended red blood cells prepared from the whole blood of Tibetan male residents

CCPortal

DOI	10.3389/fmed.2022.1062778
	A study on the correlation between hemoglobin concentration and the storage quality of suspended red blood cells prepared from the whole blood of Tibetan male residents
	Zhong, Rui; Wu, Xiaodong; Liu, Zhijuan; He, Zeng; Zhang, Xuejun; Liu, Jiaxin; Cao, Ye; Wang, Hong
发表日期	2023
EISSN	2296-858X
卷号	9
英文摘要	BackgroundPrevious studies reported that the blood of Tibetans living at different altitudes may vary slightly. There is evidence that the harsh environmental conditions at high altitudes, such as low pressure and hypoxia, may affect the morphology and hemorheology of red blood cells (RBCs). Hypoxia would increase the levels of hemoglobin ([Hb]) and hematocrit (Hct), potentially increasing blood hyperviscosity and compromising blood collection and transfusions. Therefore, it is critical to investigate the in vitro storage quality of Tibetan RBCs. ObjectivesIn this study, the in vitro quality of suspended RBCs (SRBCs) prepared from whole blood (WB) of Tibetan residents with varying Hb concentrations ([Hb]) was measured during storage, and the relationship between the major factors in RBC storage and [Hb] was studied. Materials and methodsThe WB of Tibetan men was divided into three groups based on [Hb] levels (group A: 120 < Hb <= 185 g/L; group B: 185 < Hb <= 210 g/L; group C: Hb > 210 g/L). The SRBCs prepared from WB were examined aseptically on days 1, 14, 21, and 35 after storage. Results[Hb] was not correlated with mean corpuscular volume (MCV), adenosine triphosphate (ATP), pH, P50, and hemolysis. There was a moderate or strong negative association between platelets (PLT) and [Hb] from days 1 to 35, and the PLT number of group C was lower than group A during storage. Group C had the highest change rates of electrolytes, glucose, and lactate, and there were moderate or strong positive correlations between lactate and [Hb] (r = 0.3772, p = 0.0045), glucose and [Hb] (r = 0.5845, p < 0.0001), Na+ and [Hb] (r = 0.3966, p = 0.0027), and K+ and [Hb] (r = 0.4885, p = 0.0002). Group B had the highest change rates of 2,3-DPG on day 35, and there was a negative correlation between 2,3-DPG and [Hb] (r = -0.4933, p = 0.0001). ConclusionsThese new data on the [Hb] could have implications for researchers wishing to study the storage quality of Tibetan SRBCs, particularly in the context of erythrocyte metabolism, and we propose finding a new, suitable alternative solution for plateau SRBCs, particularly the blood with [Hb] greater than 185 g/L. Our results could have important implications for researchers wishing to study the potential framework of high-altitude-induced SRBC storage lesions.
关键词	high altitude hemoglobin concentration storage quality suspended red blood cells erythrocyte metabolism
英文关键词	HIGH-ALTITUDE; PLATELET COUNT; ADAPTATION; OXYGEN; THROMBOPOIETIN; BINDING
WOS研究方向	Medicine, General & Internal
WOS记录号	WOS:000924389200001
来源期刊	FRONTIERS IN MEDICINE
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283671
作者单位	Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Institute of Blood Transfusion - CAMS
推荐引用方式 GB/T 7714	Zhong, Rui,Wu, Xiaodong,Liu, Zhijuan,et al. A study on the correlation between hemoglobin concentration and the storage quality of suspended red blood cells prepared from the whole blood of Tibetan male residents[J],2023,9.
APA	Zhong, Rui.,Wu, Xiaodong.,Liu, Zhijuan.,He, Zeng.,Zhang, Xuejun.,...&Wang, Hong.(2023).A study on the correlation between hemoglobin concentration and the storage quality of suspended red blood cells prepared from the whole blood of Tibetan male residents.FRONTIERS IN MEDICINE,9.
MLA	Zhong, Rui,et al."A study on the correlation between hemoglobin concentration and the storage quality of suspended red blood cells prepared from the whole blood of Tibetan male residents".FRONTIERS IN MEDICINE 9(2023).