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DOI	10.3389/fendo.2023.1229659
	Distinctive biochemistry profiles associated with hyperuricemia between Tibetans and Hans in China
	Ren, Xue-Wen; Chen, Kang; Wu, Jue; Yang, Zhang-Lin; Ji, Tao; Zhang, Qing-Hong
发表日期	2023
ISSN	1664-2392
卷号	14
英文摘要	Purpose: We sought to identify distinct risk factors for hyperuricemia in native Tibetan and immigrant Han populations in Tibet, China.Methods: Three cohorts of male participants aged between 20 and 40 years were enrolled in this study. Biochemical parameters including serum uric acid (UA), fasting plasma glucose, insulin, lactate dehydrogenase (LDH), thyroxin, blood cell count, aminotransferase, and lipid profiles were analyzed. The association of risk factors with UA levels was evaluated using a multivariable line regression model. The effect of UA level on the biochemical parameters between the Hans and Tibetans was evaluated by two-way ANOVA.Results: The prevalence of hyperuricemia (>= 420 mu mol/L) was 24.8% (62/250) in the Hans, similar to 23.8% (29/136) in the Tibetans. In the regression analysis, the risk factors that were significantly associated with UA in Hans did not apply to Tibetans. Tibetans had higher fasting insulin (P<0.05) and LDH (P<0.01) levels, in contrast with lower levels of triglycerides (P<0.05), total cholesterol (P<0.01), and low-density lipoprotein-cholesterol (P<0.01) than Hans in normal UA populations. Biochemistry analysis revealed lower albumin levels (P<0.001) and higher levels of all aminotransaminase and especially alkaline phosphatase (P<0.01) in Tibetans than in Hans in both populations. Compared with Hans, Tibetans had lower serum levels of urea, creatinine, and electrolytes in the normal UA population, which were further exacerbated in the high UA population. Tibetans had comparable white blood cell counts as Hans in both normal and high UA populations. In contrast, the red blood cell count and hemoglobin concentration were much lower in Tibetans than in Hans under high UA conditions.Conclusions: The distinctive biochemistry between Tibetans and Hans may underlie the different etiologies of hyperuricemia in Tibet, China. [Graphical Abstract]
关键词	Tibetan hyperuricemia hypoxia glycolysis aminotransferase lipid metabolism red blood cell
英文关键词	HIGH-ALTITUDE ADAPTATION; NONSPECIFIC ALKALINE-PHOSPHATASE; URIC-ACID; INSULIN-RESISTANCE; METABOLIC SYNDROME; HYPOXIA; PREVALENCE; DISEASE; GLUCOSE; EXCRETION
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001123787300001
来源期刊	FRONTIERS IN ENDOCRINOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283622
推荐引用方式 GB/T 7714	Ren, Xue-Wen,Chen, Kang,Wu, Jue,et al. Distinctive biochemistry profiles associated with hyperuricemia between Tibetans and Hans in China[J],2023,14.
APA	Ren, Xue-Wen,Chen, Kang,Wu, Jue,Yang, Zhang-Lin,Ji, Tao,&Zhang, Qing-Hong.(2023).Distinctive biochemistry profiles associated with hyperuricemia between Tibetans and Hans in China.FRONTIERS IN ENDOCRINOLOGY,14.
MLA	Ren, Xue-Wen,et al."Distinctive biochemistry profiles associated with hyperuricemia between Tibetans and Hans in China".FRONTIERS IN ENDOCRINOLOGY 14(2023).