气候变化领域集成服务门户(CCPortal): Quantitative Proteomic Analysis of Tibetan Pig Livers at Different Altitudes

CCPortal

DOI	10.3390/molecules28041694
	Quantitative Proteomic Analysis of Tibetan Pig Livers at Different Altitudes
	Gu, Xuedong; Chang, Xinping; Yang, Lin; Chamba, Yangzom; Geng, Fang
发表日期	2023
EISSN	1420-3049
卷号	28 期号:4
英文摘要	In this study, the differences in protein profiles between the livers of Shannan Tibetan pigs (SNT), Linzhi Tibetan pigs (LZT) and Jiuzhaigou Tibetan pigs (JZT) were comparatively analyzed by tandem mass spectrometry-labeling quantitative proteomics. A total of 6804 proteins were identified: 6471 were quantified and 1095 were screened as differentially expressed proteins (DEPs). Bioinformatics analysis results show that, compared with JZT livers, up-regulated DEPs in SNT and LZT livers mainly promoted hepatic detoxification through steroid hormone biosynthesis and participated in lipid metabolism to maintain body energy homeostasis, immune response and immune regulation, while down-regulated DEPs were mainly involved in lipid metabolism and immune regulation. Three proteases closely related to hepatic fatty acid oxidation were down-regulated in enzymatic activity, indicating higher levels of lipid oxidation in SNT and LZT livers than in JZT livers. Down-regulation of the expression of ten immunoglobulins suggests that JZT are more susceptible to autoimmune diseases. It is highly likely that these differences in lipid metabolism and immune-related proteins are in response to the ecological environment at different altitudes, and the findings contribute to the understanding of the potential molecular link between Tibetan pig livers and the environment.
关键词	Tibetan pig proteomics liver lipid metabolism immunoglobulin
英文关键词	EXPRESSION; CELLS; GENE
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000940994100001
来源期刊	MOLECULES
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283618
作者单位	Tibet Agriculture & Animal Husbandry University; Chengdu University
推荐引用方式 GB/T 7714	Gu, Xuedong,Chang, Xinping,Yang, Lin,et al. Quantitative Proteomic Analysis of Tibetan Pig Livers at Different Altitudes[J],2023,28(4).
APA	Gu, Xuedong,Chang, Xinping,Yang, Lin,Chamba, Yangzom,&Geng, Fang.(2023).Quantitative Proteomic Analysis of Tibetan Pig Livers at Different Altitudes.MOLECULES,28(4).
MLA	Gu, Xuedong,et al."Quantitative Proteomic Analysis of Tibetan Pig Livers at Different Altitudes".MOLECULES 28.4(2023).