气候变化领域集成服务门户(CCPortal): Prevalence and risk factors for dementia in the Tibetan region: A population-based cross-sectional study

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DOI	10.1016/j.jad.2023.04.075
	Prevalence and risk factors for dementia in the Tibetan region: A population-based cross-sectional study
	Mima, Dunzhu; Wang, Li-ping; Zhai, Yun; De, Qing; Ba, Song; Da, Ga; Wang, Bin-you; Zhao, Jing-bo; Tang, Ying
发表日期	2023
ISSN	0165-0327
EISSN	1573-2517
起始页码	159
结束页码	165
卷号	334
英文摘要	Background: As China's population ages, the nationwide prevalence of dementia is increasing. However, the epidemiology of dementia among the Tibetan population remains unclear.Objective: A cross-sectional study was conducted involving 9116 participants aged >50 years in the Tibetan population to investigate the risk factors and prevalence of dementia among this population. Permanent residents of the region were invited to participate, and the response rate was 90.7 %.Methods: The participants underwent neuropsychological testing and clinical assessments, from which physical measurements (e.g., body mass index, blood pressure), demographic information (e.g., gender, age), and lifestyle details (e.g., family living arrangement, smoking, alcohol arrangement) were recorded. Dementia diagnoses were made using the standard consensus diagnostic criteria. The risk factors of dementia were identified using step-wise multiple logistic regression.Results: The average age of the participants was 63.71 (standard deviation = 9.36), and there were 44.86 % males. The prevalence of dementia was 4.66 %. The multivariate logistic regression analysis revealed that older age, unmarried status, lower education level, obesity, hypertension, diabetes, coronary heart disease, cerebral vascular disease, and HAPC were independently and positively associated with dementia (P < 0.05). However, no association was found between the frequency of religious activities and the prevalence of dementia in this population (P > 0.05).Conclusions: There exist a number of contributory risk factors for dementia in the Tibetan population, with variations associated with high altitude, religious activities (i.e., scripture turning, chanting, spinning Buddhist beads, and bowing), and dietary habits. These findings suggest that social activities, such as religious activities, are protective factors for dementia.
关键词	Aging Dementia Tibetan population Prevalence Risk factors High -altitude polycythemia
英文关键词	ALZHEIMERS-DISEASE; COGNITIVE FUNCTION; VASCULAR DEMENTIA; ASSOCIATION; PATTERNS; SUBTYPES; DECLINE; VERSION; DESIGN; URBAN
WOS研究方向	Clinical Neurology ; Psychiatry
WOS记录号	WOS:001006505600001
来源期刊	JOURNAL OF AFFECTIVE DISORDERS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283611
作者单位	Peking University; Harbin Medical University; Harbin Medical University
推荐引用方式 GB/T 7714	Mima, Dunzhu,Wang, Li-ping,Zhai, Yun,et al. Prevalence and risk factors for dementia in the Tibetan region: A population-based cross-sectional study[J],2023,334.
APA	Mima, Dunzhu.,Wang, Li-ping.,Zhai, Yun.,De, Qing.,Ba, Song.,...&Tang, Ying.(2023).Prevalence and risk factors for dementia in the Tibetan region: A population-based cross-sectional study.JOURNAL OF AFFECTIVE DISORDERS,334.
MLA	Mima, Dunzhu,et al."Prevalence and risk factors for dementia in the Tibetan region: A population-based cross-sectional study".JOURNAL OF AFFECTIVE DISORDERS 334(2023).