气候变化领域集成服务门户(CCPortal): Maternal genetic history of ancient Tibetans over the past 4000 years

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DOI	10.1016/j.jgg.2023.03.007
	Maternal genetic history of ancient Tibetans over the past 4000 years
	Zhang, Ganyu; Cui, Can; Shargan, Wangdue; Lu, Hongliang; Chen, Honghai; Xi, Lin; He, Wei; Yuan, Haibing; Tsring, Tinley; Chen, Zujun; Yang, Feng; Tsering, Tashi; Li, Shuai; Tashi, Norbu; Yang, Tsho; Tong, Yan; Wu, Xiaohong; Li, Linhui; He, Yuanhong; Cao, Peng; Dai, Qingyan; Liu, Feng; Feng, Xiaotian; Wang, Tianyi; Yang, Ruowei; Ping, Wanjing; Zhang, Ming; Gao, Xing; Liu, Yichen; Wang, Wenjun; Fu, Qiaomei
发表日期	2023
ISSN	1673-8527
EISSN	1873-5533
起始页码	765
结束页码	775
卷号	50 期号:10
英文摘要	The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity. Here, we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet. The phylogeny of haplotypes M9a1a, M9a1b, D4g2, G2a'c, and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene. In addition, the connections between Tibetans and Northeastern Asians vary over the past 4000 years, with a stronger matrilineal connection between the two during 4000 BP-3000 BP, and a weakened connection after 3000 BP, that are coincident with climate change, followed by a reinforced connection after the Tubo period (1400 BP-1100 BP). Besides, an over 4000-year matrilineal continuity is observed in some of the maternal lineages. We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations. Overall, the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography, climate changes, as well as historical events.Copyright (c) 2023, The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
关键词	Ancient DNA Tibetans Population history Mitochondrial genome
英文关键词	POPULATION-GENETICS; GENOME SEQUENCE; PLATEAU; NORTHERN; CHINA; EVOLUTION; CAVE; TEMPERATURE; MIGRATIONS; SETTLEMENT
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号	WOS:001105427200001
来源期刊	JOURNAL OF GENETICS AND GENOMICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283610
作者单位	Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Sichuan University; Northwest University Xi'an; Peking University
推荐引用方式 GB/T 7714	Zhang, Ganyu,Cui, Can,Shargan, Wangdue,et al. Maternal genetic history of ancient Tibetans over the past 4000 years[J],2023,50(10).
APA	Zhang, Ganyu.,Cui, Can.,Shargan, Wangdue.,Lu, Hongliang.,Chen, Honghai.,...&Fu, Qiaomei.(2023).Maternal genetic history of ancient Tibetans over the past 4000 years.JOURNAL OF GENETICS AND GENOMICS,50(10).
MLA	Zhang, Ganyu,et al."Maternal genetic history of ancient Tibetans over the past 4000 years".JOURNAL OF GENETICS AND GENOMICS 50.10(2023).