气候变化领域集成服务门户(CCPortal): Varied hypoxia adaptation patterns of embryonic brain at different development stages between Tibetan and Dwarf laying chickens

CCPortal

DOI	10.1186/s12864-023-09457-4
	Varied hypoxia adaptation patterns of embryonic brain at different development stages between Tibetan and Dwarf laying chickens
	Tang, Qiguo; Yu, Runjie; Wang, Yubei; Xie, Fuyin; Zhang, Hao; Wu, Changxin; Fang, Meiying
发表日期	2023
ISSN	1471-2164
卷号	24 期号:1
英文摘要	BackgroundTibetan chickens (Gallus gallus; TBCs), an indigenous breed distributed in the Qinghai-Tibet Plateau, are well adapted to the hypoxic environment. Currently, the molecular genetic basis of hypoxia adaptation in TBCs remains unclear. This study investigated hypoxia adaptation patterns of embryonic brain at different development stages by integrating analysis of the transcriptome with our previously published metabolome data in TBCs and Dwarf Laying Chickens (DLCs), a lowland chicken breed.ResultsDuring hypoxia, the results revealed that 1334, 578, and 417 differentially expressed genes (DEGs) (\|log(2) fold change\|>1, p-value < 0.05) on days 8, 12, and 18 of development, respectively between TBCs and DLCs. Gene Ontology (GO) and pathway analyses revealed that DEGs are mainly related to metabolic pathways, vessel development, and immune response under hypoxia. This is consistent with our metabolome data that TBCs have higher energy metabolism than DLCs during hypoxia. Some vital DEGs between TBCs and DLCs, such as EPAS1, VEGFD, FBP1, FBLN5, LDHA, and IL-6 which are involved in the HIF pathway and hypoxia regulation.ConclusionThese results suggest varied adaptation patterns between TBCs and DLCs under hypoxia. Our study provides a basis for uncovering the molecular regulation mechanism of hypoxia adaptation in TBCs and a potential application of hypoxia adaptation research for other animals living on the Qinghai-Tibet Plateau, and may even contribute to the study of brain diseases caused by hypoxia.
关键词	Tibetan chickens RNA profile Metabolome Embryonic brain Hypoxia
英文关键词	HIGH-ALTITUDE ADAPTATION; MOLECULAR-BASIS; GROWTH; HATCHABILITY; HEMOGLOBIN; METABOLISM; SELECTION; CALCIUM; IL-6; GAS
WOS研究方向	Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS记录号	WOS:001012480100002
来源期刊	BMC GENOMICS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283605
作者单位	China Agricultural University; China Agricultural University
推荐引用方式 GB/T 7714	Tang, Qiguo,Yu, Runjie,Wang, Yubei,et al. Varied hypoxia adaptation patterns of embryonic brain at different development stages between Tibetan and Dwarf laying chickens[J],2023,24(1).
APA	Tang, Qiguo.,Yu, Runjie.,Wang, Yubei.,Xie, Fuyin.,Zhang, Hao.,...&Fang, Meiying.(2023).Varied hypoxia adaptation patterns of embryonic brain at different development stages between Tibetan and Dwarf laying chickens.BMC GENOMICS,24(1).
MLA	Tang, Qiguo,et al."Varied hypoxia adaptation patterns of embryonic brain at different development stages between Tibetan and Dwarf laying chickens".BMC GENOMICS 24.1(2023).