气候变化领域集成服务门户(CCPortal): Genetic structure and characteristics of Tibetan chickens

CCPortal

DOI	10.1016/j.psj.2023.102767
	Genetic structure and characteristics of Tibetan chickens
	Li, Shijun; Zhang, Xiaojian; Dong, Xinyu; Guo, Ruiyang; Nan, Jiuhong; Yuan, Jingwei; Schlebusch, Carina M.; Sheng, Zheya
发表日期	2023
ISSN	0032-5791
EISSN	1525-3171
卷号	102 期号:8
英文摘要	Tibetan chicken is one of the most common and widely distributed highland breeds, and is often used as a model organism for understanding genetic adaptation to extreme environments in Tibet. Despite its apparent geographical diversity and large variations in plumage patterns, the genetic differences within breed were not accounted for in most studies and have not been systematically investigated. In order to reveal and genetically differentiate the current existing TBC sub populations that might have major implications for genomic research in TBCs, we systematically evaluated the population structure and demography of current TBC populations. Based on 344 whole-genome sequenced birds including 115 Tibetan chickens that were mostly sampled from family-farms across Tibet, we revealed a clear separation of Tibetan chickens into 4 sub-populations that broadly aligns with their geographical distribution. Moreover, population structure, population size dynamics, and the extent of admixture jointly suggest complex demographic histories of these sub-populations, including possible multiple origins, inbreeding, and introgressions. While most of the candidate selected regions found between the TBC sub populations and Red Jungle fowls were nonoverlapping, 2 genes RYR2 and CAMK2D were revealed as strong selection candidates in all 4 sub-populations. These 2 previously identified high altitude associated genes indicated that the sub-populations responded to similar selection pressures in an independent but functionally similar fashion. Our results demonstrate robust population structure in Tibetan chickens that will help inform future genetic analyses on chickens and other domestic animals alike in Tibet, recommending thoughtful experimental design.
关键词	Tibetan chicken population structure complex demography genetic analyses
英文关键词	HIGH-ALTITUDE ADAPTATION; ADMIXTURE; GENOMICS; HYPOXIA; REVEAL; BREEDS; TOOL
WOS研究方向	Agriculture, Dairy & Animal Science
WOS记录号	WOS:001022435300001
来源期刊	POULTRY SCIENCE
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283580
作者单位	Huazhong Agricultural University; Huazhong Agricultural University; Huazhong Agricultural University; Chinese Academy of Agricultural Sciences; Institute of Animal Science, CAAS
推荐引用方式 GB/T 7714	Li, Shijun,Zhang, Xiaojian,Dong, Xinyu,et al. Genetic structure and characteristics of Tibetan chickens[J],2023,102(8).
APA	Li, Shijun.,Zhang, Xiaojian.,Dong, Xinyu.,Guo, Ruiyang.,Nan, Jiuhong.,...&Sheng, Zheya.(2023).Genetic structure and characteristics of Tibetan chickens.POULTRY SCIENCE,102(8).
MLA	Li, Shijun,et al."Genetic structure and characteristics of Tibetan chickens".POULTRY SCIENCE 102.8(2023).