气候变化领域集成服务门户(CCPortal): Longitudinal study on blood and biochemical indexes of Tibetan and Han in high altitude area

CCPortal

DOI	10.3389/fpubh.2023.1282051
	Longitudinal study on blood and biochemical indexes of Tibetan and Han in high altitude area
	Yuan, Zhimin; Zou, Yuanwu; Liu, Xiaoxing; Wang, Longhao; Chen, Cheng
发表日期	2023
EISSN	2296-2565
卷号	11
英文摘要	Objective: This study aims to review the blood routine and biochemical indicators of the plateau population for three consecutive years, and analyze the impact of the plateau on these blood indicators of the Tibetan population and the Han immigrant population.Method: These parameters were extracted from the Laboratory Department of Ali District People's Hospital in Tibet from January 2019 to December 2021, including blood routine, liver and kidney function, blood lipids, myocardial enzyme spectrum, and rheumatic factor indicators. Changes in these parameters were analyzed over 3 consecutive years according to inclusion and exclusion criteria.Result: A total of 114 Tibetans and 93 Hans participated in the study. These parameters were significantly different between Tibetan and Han populations. Red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), mean hemoglobin content (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cells (WBC), lymphocytes (LYMPH) and monocytes (MONO) were significantly higher in Hans than Tibetans (p < 0.05). Biochemically, total bilirubin (TBIL), direct bilirubin (DBIL), albumin (ALB), urea nitrogen (Urea), creatinine (Cr), uric acid (UA), glucose (GLU), triglycerides (TG) and creatine kinase isoenzyme (CKMB) were significantly higher in Hans than Tibetans; aspartate aminotransferase (AST), glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), antistreptolysin (ASO), and C-reactive protein (CRP) were significantly higher in Tibetans than Hans (p < 0.05). There were no obvious continuous upward or downward trend of the parameters for 3 consecutive years.Conclusion: In high-altitude areas, Han immigrants have long-term stress changes compared with Tibetans. The main differences are reflected in the blood system, liver and kidney functions, etc., which provide basic data for further research on the health status of plateau populations.
关键词	high altitude blood biochemical indexes longitudinal analysis inhabitant Tibetan
英文关键词	ADAPTATION; HYPOXIA; PHYSIOLOGY; EXPRESSION; TRANSPORT; EXPOSURE; QINGHAI; RISK
WOS研究方向	Public, Environmental & Occupational Health
WOS记录号	WOS:001122485300001
来源期刊	FRONTIERS IN PUBLIC HEALTH
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283538
作者单位	Xi'an Jiaotong University; Shanghai Jiao Tong University; Xi'an Jiaotong University
推荐引用方式 GB/T 7714	Yuan, Zhimin,Zou, Yuanwu,Liu, Xiaoxing,et al. Longitudinal study on blood and biochemical indexes of Tibetan and Han in high altitude area[J],2023,11.
APA	Yuan, Zhimin,Zou, Yuanwu,Liu, Xiaoxing,Wang, Longhao,&Chen, Cheng.(2023).Longitudinal study on blood and biochemical indexes of Tibetan and Han in high altitude area.FRONTIERS IN PUBLIC HEALTH,11.
MLA	Yuan, Zhimin,et al."Longitudinal study on blood and biochemical indexes of Tibetan and Han in high altitude area".FRONTIERS IN PUBLIC HEALTH 11(2023).