气候变化领域集成服务门户(CCPortal): Genome Variation Map of Domestic Qinghai-Tibet Plateau Yaks by SLAF-Seq Reveals Genetic Footprint during Artificial Selection

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DOI	10.3390/ani13182963
	Genome Variation Map of Domestic Qinghai-Tibet Plateau Yaks by SLAF-Seq Reveals Genetic Footprint during Artificial Selection
	Li, Biao; Yang, Jinzeng; Liu, Yili; Jiang, Mingfeng
发表日期	2023
ISSN	2076-2615
卷号	13 期号:18
英文摘要	Simple Summary The yak is endemic to the Qinghai-Tibetan Plateau (QTP) and serves as an important livestock animal for Tibetan pastoral society. Phenotypic traits vary among domestic yaks. However, genomic characteristics, population structure, and the genetic relationship of domestic yaks with wild yaks have not been effectively characterized until now. In this study, six domestic populations were sequenced, and selective sweep regions involved in yak domestication were detected. Furthermore, divergence time for domestic and wild yaks was estimated. This study revealed new insight into selection for domestic and wild yaks.Abstract The yak (Bos grunniens) was domesticated in the high-altitude QTP. Research about their genetic diversity and population structure is limited. In this study, we resequenced the genome of 494 domestic yaks using Specific-Locus Amplified Fragment Sequencing (SLAF-seq). The survey was conducted on six populations sampled from isolated locations in China in order to analyze their structure and genetic diversity. These six domestic populations were clearly grouped into two independent clusters, with Jinchuan, Changtai, and Jiulong showing a tight genetic relationship with the wild yak. Nerve development pathways were enriched with GO enrichment analysis of 334 domesticated genes. Major genomic regions associated with the differentiation of domestic yaks were detected. These findings provide preliminary information on the yak genome variability, useful to understand the genomic characteristics of different populations in QTP.
关键词	yak domestication population structure natural selection
WOS研究方向	Agriculture, Dairy & Animal Science ; Veterinary Sciences ; Zoology
WOS记录号	WOS:001151286800002
来源期刊	ANIMALS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283495
作者单位	Southwest Minzu University; Southwest Minzu University; University of Hawaii System; University of Hawaii Manoa; Southwest Minzu University
推荐引用方式 GB/T 7714	Li, Biao,Yang, Jinzeng,Liu, Yili,et al. Genome Variation Map of Domestic Qinghai-Tibet Plateau Yaks by SLAF-Seq Reveals Genetic Footprint during Artificial Selection[J],2023,13(18).
APA	Li, Biao,Yang, Jinzeng,Liu, Yili,&Jiang, Mingfeng.(2023).Genome Variation Map of Domestic Qinghai-Tibet Plateau Yaks by SLAF-Seq Reveals Genetic Footprint during Artificial Selection.ANIMALS,13(18).
MLA	Li, Biao,et al."Genome Variation Map of Domestic Qinghai-Tibet Plateau Yaks by SLAF-Seq Reveals Genetic Footprint during Artificial Selection".ANIMALS 13.18(2023).