气候变化领域集成服务门户(CCPortal): Risk factors for microalbuminuria in adult Tibetan patients with high-altitude pulmonary hypertension: a cross-sectional study

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DOI	10.21037/cdt-22-385
	Risk factors for microalbuminuria in adult Tibetan patients with high-altitude pulmonary hypertension: a cross-sectional study
	Yuan, Cuizhen; Zhang, Qian
发表日期	2023
ISSN	2223-3652
EISSN	2223-3660
起始页码	336
结束页码	344
卷号	13 期号:2
英文摘要	Background: It has been suggested that chronic hypoxia underlies the higher prevalence of microalbuminuria in high-altitude residents than in sea-level dwellers. This study explored the risk factors for microalbuminuria in Tibetans with high-altitude pulmonary hypertension (HAPH).Methods: This retrospective cross-sectional study included adult patients with HAPH admitted to the People's Hospital of Tibet Autonomous Region between November 2018 and August 2019. Results: One hundred and twenty patients with HAPH were included in this study, and 69 patients (57.5%) had microalbuminuria. Compared with the patients without microalbuminuria, the microalbuminuria group had significantly higher values for age, pulmonary arterial systolic pressure (PASP), systolic blood pressure, diastolic blood pressure, blood hemoglobin concentration, glycated hemoglobin, serum creatinine, and serum uric acid, significantly lower values for heart rate, peripheral oxygen saturation (SpO2), estimated glomerular filtration rate, and 6-min walking distance, and poorer New York Heart Association functional class (P<0.05 for all variables). PASP [odds ratio (OR): 1.55; 95% CI: 1.19-2.00; P=0.001] and SpO2 (OR = 0.78; 95% CI: 0.63-0.97; P=0.02) were independently associated with microalbuminuria.Conclusions: Higher PASP and lower SpO2 were independently associated with microalbuminuria in adult Tibetan patients with HAPH.
关键词	Altitude hypoxia pulmonary hypertension oxygen saturation albuminuria risk factors
英文关键词	CHRONIC KIDNEY-DISEASE; ENDOTHELIAL DYSFUNCTION; ADAPTATION; PATHOGENESIS; PREVALENCE; MARKER
WOS研究方向	Cardiac & Cardiovascular Systems
WOS记录号	WOS:000962862400001
来源期刊	CARDIOVASCULAR DIAGNOSIS AND THERAPY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283470
作者单位	Peking University; Peking University
推荐引用方式 GB/T 7714	Yuan, Cuizhen,Zhang, Qian. Risk factors for microalbuminuria in adult Tibetan patients with high-altitude pulmonary hypertension: a cross-sectional study[J],2023,13(2).
APA	Yuan, Cuizhen,&Zhang, Qian.(2023).Risk factors for microalbuminuria in adult Tibetan patients with high-altitude pulmonary hypertension: a cross-sectional study.CARDIOVASCULAR DIAGNOSIS AND THERAPY,13(2).
MLA	Yuan, Cuizhen,et al."Risk factors for microalbuminuria in adult Tibetan patients with high-altitude pulmonary hypertension: a cross-sectional study".CARDIOVASCULAR DIAGNOSIS AND THERAPY 13.2(2023).