气候变化领域集成服务门户(CCPortal): Divergent contributions of coding and noncoding sequences to initial high-altitude adaptation in passerine birds endemic to the Qinghai-Tibet Plateau

CCPortal

DOI	10.1111/mec.16942
	Divergent contributions of coding and noncoding sequences to initial high-altitude adaptation in passerine birds endemic to the Qinghai-Tibet Plateau
	Hao, Yan; Song, Gang; Zhang, Yong E.; Zhai, Weiwei; Jia, Chenxi; Ji, Yanzhu; Tang, Shiyu; Lv, Hongrui; Qu, Yanhua; Lei, Fumin
发表日期	2023
ISSN	0962-1083
EISSN	1365-294X
起始页码	3524
结束页码	3540
卷号	32 期号:13
英文摘要	Early events in the evolution of an ancestral lineage can shape the adaptive patterns of descendant species, but the evolutionary mechanisms driving initial adaptation from an ancestor remain largely unexplored. High-altitude adaptations have been extensively explored from the viewpoint of protein-coding genes; however, the contribution of noncoding regions remains relatively neglected. Here, we integrate genomic and transcriptomic data to investigate adaptive evolution in the ancestor of three high-altitude snowfinch species endemic to the Qinghai-Tibet Plateau. Our genome-wide scan for adaptation in the snowfinch ancestor identifies strong adaptation signals in functions of development and metabolism for the coding genes, but in functions of the nervous system development for noncoding regions. This pattern is exclusive to the snowfinch ancestor compared to a control ancestral lineage subject to weak selection. Changes in noncoding regions in the snowfinch ancestor, especially those nearest to coding genes, may be disproportionately associated with the differential expression of genes in the brain tissue compared to other tissues. Extensive gene expression in the brain tissue can be further altered via genetic regulatory networks of transcription factors harbouring potential accelerated regulatory regions (e.g., the development-related transcription factor YEATS4). Altogether, our study provides new evidence concerning how coding and noncoding sequences work through decoupled pathways in initial adaptation to the selective pressure of high-altitude environments. The analysis highlights the idea that noncoding sequences may be promising elements in facilitating the rapid evolution and adaptation to high altitudes.
关键词	adaptive evolution brain gene expression high altitude noncoding
英文关键词	ACCELERATED EVOLUTION; HYPOXIA-TOLERANCE; GENOME; BRAIN; SELECTION; ALIGNMENT; REGIONS; PATHWAY; IDENTIFICATION; ANNOTATION
WOS研究方向	Biochemistry & Molecular Biology ; Ecology ; Evolutionary Biology
WOS记录号	WOS:000963990400001
来源期刊	MOLECULAR ECOLOGY
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283286
作者单位	Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences
推荐引用方式 GB/T 7714	Hao, Yan,Song, Gang,Zhang, Yong E.,et al. Divergent contributions of coding and noncoding sequences to initial high-altitude adaptation in passerine birds endemic to the Qinghai-Tibet Plateau[J],2023,32(13).
APA	Hao, Yan.,Song, Gang.,Zhang, Yong E..,Zhai, Weiwei.,Jia, Chenxi.,...&Lei, Fumin.(2023).Divergent contributions of coding and noncoding sequences to initial high-altitude adaptation in passerine birds endemic to the Qinghai-Tibet Plateau.MOLECULAR ECOLOGY,32(13).
MLA	Hao, Yan,et al."Divergent contributions of coding and noncoding sequences to initial high-altitude adaptation in passerine birds endemic to the Qinghai-Tibet Plateau".MOLECULAR ECOLOGY 32.13(2023).