气候变化领域集成服务门户(CCPortal): GENOME-WIDE ANALYSIS REVEALS THE MOLECULAR BASIS OF GENETIC VARIATION OF IMPORTANT ECONOMIC TRAITS IN CASHMERE GOATS ON QINGHAI-TIBET PLATEAU

CCPortal

DOI	10.36899/JAPS.2023.6.0687
	GENOME-WIDE ANALYSIS REVEALS THE MOLECULAR BASIS OF GENETIC VARIATION OF IMPORTANT ECONOMIC TRAITS IN CASHMERE GOATS ON QINGHAI-TIBET PLATEAU
	Tian, D.; Zhou, B. C.; Han, B.; Li, X.; Tian, F.; Qi, D.; Zhao, K.
发表日期	2023
ISSN	1018-7081
EISSN	2309-8694
起始页码	1474
结束页码	1489
卷号	33 期号:6
英文摘要	Qaidam Cashmere goat is one of the few animals that can survive in the harsh environment of the Qinghai-Tibet Plateau and the adjacent alpine areas. It has a strong adaptability, thus shaping the genetic diversity of goat phenotype, morphology, physiology and other aspects. However, the molecular basis behind these genetic mechanisms remains unclear. Here, we conducted genome-wide studies of genetic variation in two different morphologies and geographical coordinates in indigenous Chinese goats to identify selective signaling in genomic regions. In the present study, we resequenced 10 high-altitude Chinese indigenous goat breeds and compared them with low-altitude goats. By combining theta pi and Fst values, we identified 1277 overlapping selection regions that may contribute to the wool fiber traits, reproductive performance, and high-altitude adaptation of goats. Candidate genes enriched in selected regions are associated with the phenotypes in cashmere fiber traits ( IGFBP3, TNF, ROCK1, WNT10B, KITLG), reproduction traits (CAMK2D, IL-18, ESR1, ANAPC13), body size (POMC), hypoxic adaptation (TH, ACER1, GNB1, HIF1A) and disease (IL-10). This study provided valuable genetic information for the basis of biological characteristics and genetic improvement of breeds.
关键词	cashmere goat whole-genome resequencing adaptability candidate genes
英文关键词	PROVIDES INSIGHTS; ADAPTATION; ASSOCIATION; POLYMORPHISMS; SYSTEM; MODEL
WOS研究方向	Agriculture, Multidisciplinary ; Biology ; Veterinary Sciences
WOS记录号	WOS:001149087800022
来源期刊	JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283244
作者单位	Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Qinghai University
推荐引用方式 GB/T 7714	Tian, D.,Zhou, B. C.,Han, B.,et al. GENOME-WIDE ANALYSIS REVEALS THE MOLECULAR BASIS OF GENETIC VARIATION OF IMPORTANT ECONOMIC TRAITS IN CASHMERE GOATS ON QINGHAI-TIBET PLATEAU[J],2023,33(6).
APA	Tian, D..,Zhou, B. C..,Han, B..,Li, X..,Tian, F..,...&Zhao, K..(2023).GENOME-WIDE ANALYSIS REVEALS THE MOLECULAR BASIS OF GENETIC VARIATION OF IMPORTANT ECONOMIC TRAITS IN CASHMERE GOATS ON QINGHAI-TIBET PLATEAU.JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS,33(6).
MLA	Tian, D.,et al."GENOME-WIDE ANALYSIS REVEALS THE MOLECULAR BASIS OF GENETIC VARIATION OF IMPORTANT ECONOMIC TRAITS IN CASHMERE GOATS ON QINGHAI-TIBET PLATEAU".JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS 33.6(2023).