气候变化领域集成服务门户(CCPortal): Thermokarst lakes are hotspots of antibiotic resistance genes in permafrost regions on the Qinghai-Tibet Plateau

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DOI	10.1016/j.envpol.2024.123334
	Thermokarst lakes are hotspots of antibiotic resistance genes in permafrost regions on the Qinghai-Tibet Plateau
	Ren, Ze; Zhang, Cheng; Li, Xia; Luo, Wei
发表日期	2024
ISSN	0269-7491
EISSN	1873-6424
卷号	344
英文摘要	Antibiotic resistance genes (ARGs) are natural products and emerging pollutants in remote environments, including permafrost regions that are rapidly thawing due to climate warming. We investigated the role of thermokarst lakes (including sediment and water) in reserving ARGs compared to permafrost soils across the permafrost regions on the Qinghai-Tibet Plateau. As intrinsically connected distinct environments, permafrost soil, lake sediment, and lake water harbored 1239 ARGs in total, while a considerable number of same ARGs (683 out of 1239) concurrently presented in all these environments. Soil and sediment had a higher number of ARGs than water. Multidrug resistance genes were the most diverse and abundant in all three environments, where cls, ropB, mdfA, fabI, and macB were the top five most abundant ARGs while with different orders. Soil and sediment had similar ARG profiles, and the alpha and beta diversity of ARGs in sediment were positively correlated with that in soil. The beta diversity of ARG profiles between sediment and soil was highly contributed by turnover component (89%). However, turnover and nestedness components were almost equality contributed (46%-54%) to the beta diversity of ARG profiles between soil and water as well as between sediment and water. The results suggested that thermokarst lake sediments might inherit the ARGs in permafrost soils. Water ARGs are the subset of soil ARGs and sediment ARGs to a certain degree with species turnover playing a significant role. When accounting the ARGs in sediment and water together, thermokarst lakes had a significantly higher number of ARGs than permafrost soils, suggesting that thermokarst lakes act as the hotspots of ARGs in permafrost regions. These findings are disturbing especially due to the fact that tremendous number of thermokarst lakes are forming under accelerating climate change.
关键词	Antibiotic resistance genes Thermokarst process Global change Metagenomic Permafrost
英文关键词	CLIMATE-CHANGE; ARGS; SOIL; VULNERABILITY; INCREASES; MECHANISM; RESISTOME
WOS研究方向	Environmental Sciences
WOS记录号	WOS:001156741400001
来源期刊	ENVIRONMENTAL POLLUTION
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283197
作者单位	Chinese Academy of Sciences; Nanjing Institute of Geography & Limnology, CAS; Beijing Normal University; Beijing Normal University; Beijing Normal University Zhuhai; Ministry of Natural Resources of the People's Republic of China; Polar Research Institute of China; Shanghai Jiao Tong University; Zhejiang University
推荐引用方式 GB/T 7714	Ren, Ze,Zhang, Cheng,Li, Xia,et al. Thermokarst lakes are hotspots of antibiotic resistance genes in permafrost regions on the Qinghai-Tibet Plateau[J],2024,344.
APA	Ren, Ze,Zhang, Cheng,Li, Xia,&Luo, Wei.(2024).Thermokarst lakes are hotspots of antibiotic resistance genes in permafrost regions on the Qinghai-Tibet Plateau.ENVIRONMENTAL POLLUTION,344.
MLA	Ren, Ze,et al."Thermokarst lakes are hotspots of antibiotic resistance genes in permafrost regions on the Qinghai-Tibet Plateau".ENVIRONMENTAL POLLUTION 344(2024).