气候变化领域集成服务门户(CCPortal): Comparative Analysis of Metabolites between Different Altitude Schizothorax nukiangensis (Cyprinidae, Schizothoracine) on the Qinghai-Tibet Plateau in Nujiang River

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DOI	10.3390/w15020284
	Comparative Analysis of Metabolites between Different Altitude Schizothorax nukiangensis (Cyprinidae, Schizothoracine) on the Qinghai-Tibet Plateau in Nujiang River
	Xu, Weitong; Zhu, Fengyue; Wang, Dengqiang; Chen, Daqing; Duan, Xinbin; Liu, Mingdian; Li, Dapeng
发表日期	2023
EISSN	2073-4441
卷号	15 期号:2
英文摘要	In order to investigate the influence of the high-altitude aquatic environment on indigenous fish metabolites, metabolomics studies were applied in this study. Widespread throughout the main stem of the Nujiang River of Schizothorax nukiangensis, we established sampling sites at high (3890 m) and low (2100 m) altitudes and selected six S. nukiangensis at each location, each weighing approximately 150 g and looking healthy. Then, metabolomics analysis was performed to compare the various metabolites of the two groups. Low concentrations of amino acids, dipeptides, eicosapentaenoic acid, docosahexaenoic acid, pentadecanoic acid, Thioetheramide-PC, 1,2-dioleoyl-sn-glycero-3-phosphatidylcholine, 1-Stearoyl-sn-glycerol-3-phosphocholine, 1-Myristoyl-sn-glycero-3-phosphocholine and 1-Palmitoyl-sn-glycero-3-phosphocholine, high concentrations in S-Methyl-5'-thioadenosine, creatine, D-mannose-6-phosphate, D-mannose-1-phosphate, oleic acid and myristoleic acid were found in high-altitude fish liver. These differentially accumulated metabolites were involved in oxidative stress, energy metabolism, carbohydrate metabolism and lipid metabolism. mTOR signaling pathway, apoptosis and lysosome were the KEGG pathways that were enriched between different groups to ensure energy supply and limit tissue damage of fish at high altitudes. All these results contributed to the understanding of the high-altitude adaptation of S. nukiangensis in the Nujiang River. Nicotine and methoprene, two organic pollutants, performed differently in fish at different altitudes. Overall, our findings advanced the fundamental understanding of fish responses to high-altitude environments, adaptive mechanisms and organic contaminants pollution in the Nujiang River.
关键词	Qinghai-Tibet Plateau Schizothorax nukiangensis altitude metabonomics adaptation
英文关键词	FATTY-ACIDS; OXIDATIVE STRESS; MOLECULAR PHYLOGENY; ORGANIC POLLUTANTS; FISH; ADAPTATION; METHOPRENE; NICOTINE; WATER; METABOLOMICS
WOS研究方向	Environmental Sciences ; Water Resources
WOS记录号	WOS:000927174800001
来源期刊	WATER
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283054
作者单位	Huazhong Agricultural University; Chinese Academy of Fishery Sciences; Yangtze River Fisheries Research Institute, CAFS
推荐引用方式 GB/T 7714	Xu, Weitong,Zhu, Fengyue,Wang, Dengqiang,et al. Comparative Analysis of Metabolites between Different Altitude Schizothorax nukiangensis (Cyprinidae, Schizothoracine) on the Qinghai-Tibet Plateau in Nujiang River[J],2023,15(2).
APA	Xu, Weitong.,Zhu, Fengyue.,Wang, Dengqiang.,Chen, Daqing.,Duan, Xinbin.,...&Li, Dapeng.(2023).Comparative Analysis of Metabolites between Different Altitude Schizothorax nukiangensis (Cyprinidae, Schizothoracine) on the Qinghai-Tibet Plateau in Nujiang River.WATER,15(2).
MLA	Xu, Weitong,et al."Comparative Analysis of Metabolites between Different Altitude Schizothorax nukiangensis (Cyprinidae, Schizothoracine) on the Qinghai-Tibet Plateau in Nujiang River".WATER 15.2(2023).