气候变化领域集成服务门户(CCPortal): Ephedrine and pseudoephedrine in Ephedra saxatilis on the vertical altitude gradient changed in southern Tibet Plateau, China

CCPortal

DOI	10.1371/journal.pone.0290696
	Ephedrine and pseudoephedrine in Ephedra saxatilis on the vertical altitude gradient changed in southern Tibet Plateau, China
	Lu, Mengnan; Zhang, Yongjuan; Wang, Shiyan; Wang, Xiaona; Zhang, Shengnan; De, Ji
发表日期	2023
ISSN	1932-6203
卷号	18 期号:8
英文摘要	Ephedra is one of the world's most important plants, used in medicine, plants and ecology. Most Ephedra grows in plain areas and is stable. But the plateau environment is special, with the change of altitude, the variety difference of plateau Ephedra saxatilis is very obvious. E. saxatilis metabolism on the Tibetan Plateau is not only affected by altitude, but also environmental conditions such as climate conditions and different soil components. However, the change mechanism of E. saxatilis alkaloids in special ecological environment is still unclear. Therefore, we analyzed the metabolic and altitude of E. saxatilis species in the Tibetan Plateau. Through the functional analysis of Kyoto Metabolism and Metabolomic Encyclopedia (KEGG), we can determine that the number of E. saxatilis metabolites decreases with the increase of altitude, and there are differences in metabolism among the three mountains. This was confirmed by univariate analysis of the top five metabolic pathways. Based on the analysis of soil and metabolomics, it was found that soil water content was also a factor affecting E. saxatilis metabolism. According to the difference of vertical height gradient, ephedrine and pseudephedrine showed the same change in vertical altitude under different mountains. Ephedrine increased as the altitude gradient increased, and pseudoephedrine decreased as the altitude gradient decreased. Our results provide valuable information for further study of metabolic mechanism and efficacy stability. It provides useful reference for the research of E. saxatilis planting in special area.
WOS研究方向	Multidisciplinary Sciences
WOS记录号	WOS:001069265400002
来源期刊	PLOS ONE
文献类型	期刊论文
条目标识符	http://gcip.llas.ac.cn/handle/2XKMVOVA/283049
作者单位	Tibet University
推荐引用方式 GB/T 7714	Lu, Mengnan,Zhang, Yongjuan,Wang, Shiyan,et al. Ephedrine and pseudoephedrine in Ephedra saxatilis on the vertical altitude gradient changed in southern Tibet Plateau, China[J],2023,18(8).
APA	Lu, Mengnan,Zhang, Yongjuan,Wang, Shiyan,Wang, Xiaona,Zhang, Shengnan,&De, Ji.(2023).Ephedrine and pseudoephedrine in Ephedra saxatilis on the vertical altitude gradient changed in southern Tibet Plateau, China.PLOS ONE,18(8).
MLA	Lu, Mengnan,et al."Ephedrine and pseudoephedrine in Ephedra saxatilis on the vertical altitude gradient changed in southern Tibet Plateau, China".PLOS ONE 18.8(2023).